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皮肤淋巴细胞相关抗原T细胞与白癜风的研究进展 被引量：3

The relationship between CLA^+T lymphocytes and vitiligo
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摘要 白癜风是一种色素脱失性皮肤黏膜病,目前多数认为是一种T细胞异常的免疫性皮肤病。皮肤淋巴细胞相关抗原(CLA)是T淋巴细胞表面表达的一种特异的黏附分子,是记忆T淋巴细胞的皮肤归巢受体。活化的T细胞表达皮肤淋巴细胞相关抗原,对体内黑素细胞破坏从而导致白癜风发病有重要作用。对皮肤淋巴细胞相关抗原与白癜风的相关性进行研究,将更深入了解白癜风发病中T细胞的异常,并可将其作为白癜风治疗的新靶点。
作者 盛珉旻 闵仲生
机构地区 南京中医药大学第一临床医学院 江苏省中医院皮肤科
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2012年第6期387-388,共2页 Journal of Clinical Dermatology
关键词 白癜风 皮肤淋巴细胞相关抗原 T淋巴细胞 淋巴细胞归巢
分类号 R758.42 [医药卫生—皮肤病学与性病学]
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参考文献22

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同被引文献36

  • 1Thatcher JE, Welch T, Eberhart RC, et al. Thymosin 134 sus- tained release from poly ( lactide-co-glycolide ) microspheres : synthesis and implications for treatment of myocardial ischemia [J]. Acad Sci,2012,12(70) :112-119.
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  • 7Nordal E J, Guleng GE, Ronnevig JR. Treatment of vitiligo with nar- rowband-UVB (TL01) combined with tacrolimus ointment (0.1% ) vs. placebo ointment, a randomized fight/left double-blind compara-tive study[J]. J Eur Acad Dermatol Venereol,2011,25 (12) :1440 - 1443.
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  • 10Zloza A, Lyons GE, Chlewicki LK, et al. Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8 +T ceils and auto- immune vitiligo [ J ]. Autoimmunity, 2011,44 ( 8 ) : 599 - 606.

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临床皮肤科杂志
2012年 第6期

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