摘要
目的:观察羟苯磺酸钙对慢性肾功能不全患者肾功能的影响,即治疗前后患者肌酐、尿素氮、尿酸、肌酐清除率的变化及可能机制。方法:入选100例慢性肾功能不全患者,对照组40例,给予常规综合治疗,ACEI、ARB和α-酮酸等对结果有较大影响的药物不用;治疗组60例,在上述常规综合治疗基础上加用羟苯磺酸钙0.5g,3次/d。两组均观察8周。观察指标:治疗前后两组BUN、Scr、Ccr、UA。结果:(1)两组治疗前后肾功能的变化:治疗组治疗8周后BUN、Scr、Ccr即有明显变化,BUN下降(P<0.05),Scr显著下降(P<0.01),Ccr明显上升(P<0.01);对照组治疗后BUN、Scr较治疗前有所下降,Ccr稍上升,但差异无显著意义(P>0.05)。(2)将治疗组按K/DOQI标准分为A、B、C三组,分别观察治疗前后BUN、Scr的变化:与治疗前比较,Scr值明显下降,差异均有统计学意义(P<0.01),与治疗前相比,BUN值A组治疗8周后较治疗前下降(P<0.05),B、C组比较差异无统计学意义(P>0.05)。(3)两组治疗前后血UA的变化:对照组治疗前后UA下降,差异无统计学意义(P>0.05),治疗组8周后血UA明显下降(P<0.01)。结论:羟苯磺酸钙能降低患者尿素氮、肌酐的水平,显著改善慢性肾衰患者的肾功能,其机制可能是通过改善微循环而发挥作用。
Objective：To investigate chiefly the effects of calcium dobesilate on renal function in patients with chronic renal failure.Methods：100 cases of patients with chronic renal failure（CRF） were selected.40 cases of control group：general treatment of routine were given,some drugs that had a significant impact on the results weren＇t given such as ACEI,ARB and α-keto-acid etc.60 cases of treatment group：calcium dobesilate was added to the conventional treatmentbased on General above as 0.5 g,tid.Both groups was observed for 8 months.Results：（1）The changes in renal function of both groups before and after treatment：Compared with pre-treatment,there were significant changes for treatment group after eight weeks,showing BUN falling（P0.05）,Scr falling significantly（P0.01）,Ccr rising significantly（P0.01）;Although BUN,Scr falling up to a certain extent and Ccr rising slightly for control group after treatment than before,there were no significant difference.（2）The treatment group was divided into 3 groups of A,B,C according to K/DOQI Standard,and BUN,Scr changes were observed separately beforeand after treatment：compared with pre-treatment,Scr declined significantly,there were significant difference（P0.01）;BUN in group A declined after treatment of eight weeks than pre-treatment（P0.05）.Compared with pre-treatment,there were no significant difference in group B and C.（3）Changes of UA in both groups before and after treatment：Compared with pre-treatment,there were no significant difference for UA falling in control group after treatment;Compared with pre-treatment,there were significant differece for UA falling in treatment group after treatment of eight weeks（P0.01）.Conclusion：Calcium dobesilate can improve significantly renal function of patients with chronic renal failure,and reduce the level of BUN and Ccr.
出处
《中外医学研究》
2012年第14期4-6,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
