摘要
目的比较七氟醚吸入麻醉与丙泊酚静脉麻醉对心内直视手术患者CPB期间应激反应的影响。方法择期行心脏直视手术患者40例,ASAⅡ或Ⅲ级,随机均分为七氟醚组(S组)和丙泊酚组(P组)。记录诱导前(T0)、气管插管后5min(T1)、CPB后30min(T2)、CPB结束(T3)、术毕(T4)MAP、HR、BIS及血浆促肾上腺皮质激素(ACTH)和皮质醇(Cor)含量。结果与T0时比较,T1时两组MAP、BIS、ACTH、Cor均降低(P<0.05),T2～T4时ACTH、Cor均明显升高(P<0.01)。T2、T3时P组MAP、BIS、ACTH、Cor显著高于S组(P<0.05)。结论心内直视手术CPB期间七氟醚吸入麻醉较之丙泊酚静脉麻醉可显著降低机体应激反应。
Objective To investigate the effect of sevoflurane anesthesia and propofol anesthesia on endocrine stress response in patients undergoing open heart surgery during cardiopulmonary bypass（CPB）.Methods Forty ASA Ⅱ or Ⅲ patients were randomly allocated to one of two groups（n=20）：sevoflurane anesthesia group（group S） and propofol anesthesia group（group P）.MAP,HR,BIS,plasma concentration of adrenocorticotropic hormone（ACTH） and cortisol（Cor）,were recorded before induction（T0）,at 5 min after intubation（T1）,at 30 min after the initiation of CPB（T2）,at the end of CPB（T3） and operation（T4）.Results Compared with T0,MAP,HR,BIS,and levels of ACTH and Cor,decreased significantly at T1（P 〈 0.05） while ACTH and Cor increased significantly at T2-T4（P 〈 0.01） in both groups.MAP,BIS,and levels of ACTH and Cor,in group P were significantly higher than those in group S at T2-T3（P 〈 0.05）.Conclusion Sevoflurane inhalation anesthesia can more effectively inhibit the stress response in patients undergoing open heart operation during CPB than propofol anesthesia.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2012年第4期346-348,共3页
Journal of Clinical Anesthesiology
关键词
七氟醚
丙泊酚
心肺转流
应激反应
Sevoflurane； Propofol； Cardiopulmonary bypass； Stress response
