摘要
目的:探讨影响局部肌层浸润性膀胱癌患者长期生存的预后因素方法:回顾性分析2002年1月至2011年6月新疆医科大学第一附属医院肿瘤中心收治的133例局部浸润性膀胱癌患者临床资料,选择年龄、合并症、肾积水、肿瘤大小、病灶数目、T分期、淋巴结转移、病理类型、肿瘤分级、治疗方式等10个对预后可能产生影响的因素,采用Kaplan-Meier法和Log-rank检验,对有意义的单因素进行Cox多因素分析。结果:随访4～114个月,全组患者1、3、5年生存率分别为77%、64%、52%。单因素分析显示T分期、淋巴结及肾积水对预后的影响有统计学意义(P<0.05)。Cox多因素分析显示影响局部肌层浸润性膀胱癌患者预后的因素分别为:T分期(RR=2.001,P=0.001)、淋巴结(RR=2.250,P=0.045)、肾积水(RR=1.954,P=0.047)。结论:肿瘤T分期。
Objective： This study aims to investigate the prognostic factors affecting the survival of patients with local muscle-invasive bladder cancer. Methods： The clinical and follow-up data of 133 patients with local muscle-invasive bladder cancer were retrospectively analyzed. Fourteen possible prognostic factors included gender, age, nationality, smoking habits, alcohol drinking habits, coexisting disease, hydronephrosis, tumor size, multifocality, T stage, lymph node staging, pathological type, histological grade, treatments via the Kaplan-Meier method, or the Log-rank test. Multivariate analysis was performed using the Cox proportional hazard model. Results： The follow-up period ranged from 4 months to 114 months. The 1-, 3-, and 5-year survival rates were 77%, 64%, and 52%, respectively. Univariate analysis showed that the T stage, lymph node staging, and hydronephrosis were prognosis factors （ P 〈 0.05 ）. Multivariate analysis by the Cox proportional hazard model showed T stage （ RR = 2.001, P = 0.001 ）, lymph node staging （ RR =2.250, P= 0.045 ）, and hydronephrosis （ RR=1.954, P= 0.047 ） as the prognostic factors （ P〈 0.05 ）. Conclusion： Hydronephrosis, T stage, and lymph node staging were prognostic factors of local muscle-invasive bladder cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第9期593-596,共4页
Chinese Journal of Clinical Oncology
基金
乌鲁木齐市科学技术项目(编号:H111313001)资助~~
