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BOLD T2~成像评估原发性肝细胞癌患者TACE治疗前、后肝脏血氧含量的变化特点 被引量:11

BOLD T2~* imaging in evaluating oxygenation changes of patients with primary hepatocellular carcinoma before and after TACE
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摘要 目的探讨BOLD-fMRI评价原发性肝细胞癌(HCC)患者接受TACE治疗前、后的血氧变化特点及其临床应用价值。方法对10例HCC患者(HCC组)和10名健康志愿者(对照组)进行BOLD-fMRI扫描,对HCC组患者于TA-CE术后2~3周内再次行BOLD-fMRI扫描。结果 HCC组和对照组肝实质T2*值分别为(13.90±2.94)ms和(17.94±5.93)ms,差异无统计学意义(P>0.05)。HCC组TACE治疗前、后富血供HCC组织T2*值分别为(31.91±2.07)ms和(7.69±0.75)ms,差异有统计学意义(P<0.01),TACE治疗前、后肿瘤周围肝脏组织T2*值分别为(19.94±3.05)ms和(24.21±1.98)ms,差异有统计学意义(P<0.01)。结论 BOLD-fMRI能有效评测HCC患者TACE治疗前、后非瘤肝脏组织和肿瘤组织内血氧含量的变化特点。 Objective To investigate the value of BOLD-fMRI in evaluating oxygenation changes in patients with primary hepatocellular carcinoma(HCC) before and after TACE.Methods Ten patients with HCC(HCC group) and 10 volunteers(control group) underwent BOLD-fMRI,and the patients with HCC underwent BOLD-fMRI examination again 2—3 weeks after TACE.Results The mean T2* value of liver tissue in HCC group and control group was(13.90±2.94)ms and(17.94±5.93)ms,respectively(P0.05).In HCC group,the mean T2* value of tumor tissue with rich blood supply was(31.91±2.07)ms and(7.69±0.75)ms before and after TACE,respectively(P0.01),while of surrounding liver tissue was(19.94±3.05)ms and(24.21±1.98)ms,respectively(P0.01).Conclusion BOLD-fMRI can effectively evaluate the oxygenation changes of primary hepatocellular carcinoma before and after TACE.
出处 《中国医学影像技术》 CSCD 北大核心 2012年第5期939-942,共4页 Chinese Journal of Medical Imaging Technology
关键词 磁共振成像 肝肿瘤 化学栓塞 治疗性 Magnetic resonance imaging Liver neoplasms Chemoembolization therapeutic
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参考文献10

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