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CYR61/CCN1的信号传导病理学研究进展 被引量：1

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摘要 CCN1由381个氨基酸残基构成的4个独立结构模块,富含38个保守半胱氨酸的基质信号蛋白,近年来发现该信号蛋白在炎症反应、损伤修复、血管生成、肿瘤等多种病理生理过程中起重要作用,在各种疾病中成为研究热点。本文就其生物学特性和在疾病中的信号转导进行了综述。
作者 李春雷 崔文
机构地区 济南大学山东省医学科学院医学与生命科学学院基础医学研究所 济宁医学院科研处
出处 《济宁医学院学报》 2012年第2期143-145,共3页 Journal of Jining Medical University
关键词 CYR61/CCN1 信号传导
分类号 R363.1 [医药卫生—病理学]
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参考文献20

  • 1Katsube K, Sakamoto K, Tamamura Y, et al. Role of CCN, a vertebrate specific gene family, in development [J]. Dev Growth Differ, 2009,51 ( 1 ) : 55-67.
  • 2Perbal B. Alternative splicing o~ CCN mRNAs'"it has been upon us[J]. J Cell Commun Signal,2009,3(2):153-157.
  • 3Chen CC, Lau LF. Functions and mechanisms of action of CCN matricellular proteins[J]. Int J Biochem Cell Biol, 2009,41(4) :771- 783.
  • 4Dhar A, Ray A. The CCN family proteins in carcinogenesis [J]. Exp Oncol,2010,32(1) :2-9.
  • 5Kivela R,Kyrolainen H,Selanne H,et al. A single bout of ex- ercise with high mechanical loading induces the expression of CYR61/CCN1 and CTGF/CCN2 in human skeletal muscle [J]. J Appl Physiol,2007,103(4) : 1395-1401.
  • 6Wiedmaier N, Muller S, Koberle M, et al. Bacteria induce CT GF and CYR61 expression in epithelial cells in alysophospha tidic acid receptor-dependent manner[J]. Int J Med Mierobi ol, 2008,298(3-4), 231-243.
  • 7Kim JN,Kim HJ,Jeong SH, et al. Cigarette smoke-induced early growth response-1 regulates the expression of thecys- teine-rieh 61 in human skin dermal fibrohlasts[J]. Exp Der- matol,2011,20(12) :992 997.
  • 8Chuang JY,Yu NY,Chiang IP,et al. CYR61 increases matrix metalloproteinase 3 expression and cell motility in human o- ral squamous cell carcinoma cells[J]. J Cell Biochem, 2012, 10,17.
  • 9Ritz MF, Graumann U, Gutierrez B, et al. Traumatic spinal cord injury alters angiogenic factors and TGF-betal that mayaffect vascular recovery[J]. Curt Neurovasc Res,2010,7 (4):301-310.
  • 10Yu Y, Gao Y, Qin J, et al. CCN1 promotes the differentia- tion of endothelial progenitor cells and reendothelialization in the early phase after vascular injury[J]. Basic Res Cardi ol,2010,105(6) :713-724.

同被引文献20

  • 1蒋瑶祁,彭辉灿.VEGF家族及其受体与视网膜新生血管形成[J].国际眼科杂志,2006,6(5):1113-1116. 被引量：17
  • 2马焕芝,曾炳芳.CCN家族与骨的形成与修复[J].国际骨科学杂志,2007,28(2):71-73. 被引量：3
  • 3Kwon M, Libuni SK. Advances in understanding angiogenesis through molecular studies[ J ]. Int J Radiat Oncol Biol Phys ,2006,64 (1) :26-32.
  • 4Saint-Geniez M, D, Amore PA. Development and pathology of the hyaloid,choroidal and retinal vasculature [ J ]. Int J Dev Biol, 2004, 48(8) : 1045-1058.
  • 5Bar A, Dorfman SE, Fischer P, et al. The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro [ J ]. Cardiovasc Res ,2010,85 ( 4 ) : 806 -813. DOI : 10. 1093/cvr/cvp370.
  • 6Yan L,Chaqour B. Cysteine-rich protein 61 ( CCN1 ) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy[J]. J Cell Commun Signal,2013,7 (4) : 253 -263. DOI : 10. 1007/s12079-013-0206-6.
  • 7Long QZ, Zhou M, Liu XG, et al. integrin induces P-glycoprotein and Interaction of CCN1 with ctv133 confers vinblastine resistance in renal cell carcinoma cells [ J ]. Anticancer Drugs, 2013,24 ( 8 ) : 810- 817. DOI : 10. 1097/CAD. Ob013e328363046d.
  • 8Haque I, De A, Majumder M, et al. The matricellular protein CCN1/ Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis [ J ]. J Biol Chem ,2012,287 ( 46 ) : 38569 - 38579. DOI : 10. 1074/jbc. M112. 389064.
  • 9Jun JI, Lau LF. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing [ J ]. Nat Cell Biol,2010,12(7 ) : 676-685. DOI: 10. 1038/ncb2070.
  • 10Jandova J, Beyer TE, Meuillet EJ, et al. The matrix protein CCN1/ CYR61 is required for u ( V ) 135-mediated cancer cell migration [ J ]. Cell Biochem Funct, 2012,30 ( 8 ) : 687 - 695. DOI: 10. 1002/cbf. 2853.

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济宁医学院学报
2012年 第2期

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