摘要
基质信号蛋白CCN1由381个氨基酸残基构成的4个独立结构模块,富含38个保守半胱氨酸,在心血管系统具有广泛的生物学活性,影响血管内皮细胞、平滑肌细胞以及心肌细胞的分化、增殖和迁移;在血管生成、血管损伤修复、心脏发育、心肌梗死等多种病理生理过程中起重要作用。
CCN1 is a novel extracellular matrix-associated signaling protein which possesses 381 amino-acid residues to compose 4 distinct structural modules with 38 conserved cysteine residues. This protein has a variety of properties in cardiovascular system, affecting the cellular behaviors such as differentiation, proliferation and migration of vascular endothelial cells, smooth muscle cells and cardiac myocytes, that suggested an essential roles of CCN1 in angiogensis, vascular injury, cardiac development and myocardial infarction.
出处
《基础医学与临床》
CSCD
北大核心
2008年第11期1219-1222,共4页
Basic and Clinical Medicine
