摘要
磷酸二酯酶 (PDEs)迄今已报道有 9个基因家族 ,每个家族又包括多个亚家族。PDEs分布于多个组织中 ,其抑制剂具有广泛的生理作用。其中 ,PDE 4抑制剂被认为是作用于细胞内靶点的新型免疫调节、抗炎药物。新型PDE 5抑制剂sildenafil通过NO/cGMP通路舒张海绵体血管及平滑肌 ,应用于阳痿治疗取得了较好的临床效果。该文简要综述选择性PDEs抑制剂近年研究进展。
Till now, nine different gene families of phosphodiesterases(PDEs) have been isolated froma variety of tissues.Each PDE family and even members within a family also exhibit tissue , cell , and subcell specific expression patterns and therefore PDEs inhibitors have extensive physiological actions. Among these families, PDE 4 is currently considered as intracellular target for new anti inflammatory drugs and CNS drugs. Sildenafil, a selective phosphodiesterase type 5 inhibitor, specifically amplifies endogenerousc cGMP dependent relaxation in corpus cavernosum smooth muscle, and has good effect in the treatment of erectile dysfunction. In this review, a brief summarization is made on inhibitors of PDEs along with their clinical use.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第2期121-124,共4页
Chinese Pharmacological Bulletin
关键词
磷酸二酯酶抑制剂
同工酶
抗炎
抗阳痿
cyclic nucleotide phosphodiesterase inhibitor
isozyme
anti inflammatory
anti erectile dysfunction
