摘要
目的:观察西洛他唑对糖尿病周围神经病变的疗效和副作用。方法:50例糖尿病周围神经病变患者随机分为西洛他唑治疗组和维生素治疗组,分别给予西洛他唑100mg/d口服及维生素B12,维生素B1肌肉注射治疗共8周,治疗前后分别测定神经传导速度、神经症状评分和神经体征评分以判断疗效,并观察药物治疗的副作用。结果:西洛他唑治疗组对糖尿病周围神经病变疗效明显优于维生素治疗组(t=3.67,P<0.01),西洛他唑治疗后的神经传导速度(MCV中的正中神经、尺神经、胫神经、腓神经;SCV中的正中神经、尺神经、腓肠神经)、症状和体征评分均较治疗前明显改善犤治疗前的症状、体征评分分别为(5.6±0.2),(7.0±0.2)分,治疗后为(2.8±0.3),(6.4±0.3)分犦(t=2.64,2.89,P<0.01)。结论:西洛他唑对糖尿病周围神经病变有良好疗效,且副作用小。
AIM:To observe the therapeutic and side effects of cilostazol in treatment of diabetic peripheral neuropathy(DPN). METHODS:A total of 50 patients with DPN were randomized into two groups:cilostazol treatment group and vitamin treatment group. The patients in the two groups were given oral cilostazol 100 mg per day or injected with VitB12, VitB1 respectively for 8 weeks.Before and after treatment, the patients were evaluated with nerve conductive velocity(NCV), neurological syndrome score evaluation and the score of neuron system to judge the effect and observe the side effect of the drugs. RESULTS:Treatment against DPN in cilostazol group was more effective than that in vitamin group (t=3.67,P< 0.01). After cilostazol treatment,NCV(median nerve,ulnar nerve, tibial nerve, peroneal nerve in MCV and median nerve,ulnar nerve,peroneal nerve in SCV), syndrome and physical sign scores all significantly improved as compared with those before treatment:score of syndrome was from 5.6±0.2 before treatment to 2.8±0.3 after treatment, and that of physical sign was from 7.0±0.2 to 6.4±0.3(t=2.64,2.89,P< 0.01). CONCLUSION:Cilostazol is effective in the treatment of DPN and has few side effects.
出处
《中国临床康复》
CSCD
2004年第18期3523-3525,共3页
Chinese Journal of Clinical Rehabilitation
