摘要
目的探讨纳米炭混悬液在乳腺癌患者腋窝前哨淋巴结活检术中的示踪效果。方法选取我院自2009年12月至2011年12月早期乳腺癌患者、无腋窝手术史143名随机分为两组,分别注射纳米炭混悬注射液和亚甲蓝,其中纳米炭组78例,亚甲蓝组65例。实施前哨淋巴结术后所有患者加行腋窝淋巴结清扫术,比较两组的检出率、假阴性率、准确性和灵敏度。结果 1)所有患者注射纳米炭混悬液前后均未出现过敏反应,生命体征无异常。2)纳米炭混悬液染色前哨淋巴结及淋巴道清晰。3)纳米炭组SLN检出率94.8%(74/78),假阴性率6.5%(2/31),灵敏度93.5%(29/31),准确性92.3%(72/78);亚甲蓝组SLN检出率83.1%(54/65),假阴性率4.2%(1/24),灵敏度95.8%(23/24),准确性81.5%(53/65)。纳米炭组检出率明显高于亚甲蓝组(P<0.05),两组假阴性率、准确性和灵敏度差异无统计学意义(P>0.05)。结论 1)纳米炭示踪效果稳定,能清晰黑染淋巴管、淋巴结;2)纳米炭混悬注射液与亚甲蓝相比,其在乳腺癌SLNB中可操作性强。
Objective To evaluate the effect and accuracy of Carbon nanoparticles as a dye in the sentinel lymph node Biopsy （SLNB） for breast cancer through analyzing the identification rate and false negative rate in this research. Methods A total of 143 early breast cancer patients from December 2009 to February 2011 were divided into two groups,78 patients were given carbon nanoparticles suspension injection before operation,the others were given methylene blue dye. The mapping procedures and SLNB were performed using subareolar or peritumoral injection of carbon nanoparticles suspension injection or methylene blue t the site of the primary breast cancer, followed by the axillary lymph node dissection. Results 1） all patients had no allergy after injection of carbon nanoparticles. 2） The lymph node and Lymph vessel mapped by carbon nanoparticles were clear and distinct. 3） In the CNP group, the dissection rate, the false-negative, sensitivity, accuracy of SLNB were 94.8% （74/78）,6.5%（2/31）,93.5%（29/31）,92.3%（72/78）, respectively. In the methylene blue group, the detection rate false-negative, sensitivity, accuracy of SLNB were 83.1%（54/65）, 4.2% （1/24）, 95.8%（23/24）, 81.5%（53/65）. The difference of the detection rate was significant between two groups. Conclusion Carbon nanoparticles injection is a safe and suitable dye for SLNB in early breast cancer.
出处
《岭南现代临床外科》
2012年第2期118-120,共3页
Lingnan Modern Clinics in Surgery
基金
江科[2010]73号59
