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1,25二羟基维生素D_3在恶性血液病治疗中的作用 被引量:5

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摘要 1,25二羟基维生素D_3是一种有效的肿瘤诱导分化剂,它能诱导多种白血病细胞株向成熟方向分化。它的作用机理与多种因素如细胞内特异性受体、癌基因的表达、细胞内Ca^(2+)浓度等有关。为克服治疗中出现的高钙血症,已开发出多种高效低毒的维生素D类似物,以及与其他诱导分化剂、抗肿瘤药等联合应用,以减少高钙血症的发生。本文就1,25二羟基维生素D_3治疗恶性血液病的进展作一综述。
出处 《国外医学(输血及血液学分册)》 2000年第2期124-126,共3页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
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参考文献10

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同被引文献58

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