摘要
目的探讨骨髓性与非骨髓性血小板减少症患者血小板参数变化及其临床意义。方法将血小板减少症患者分为骨髓性血小板减少症组(53例)和非骨髓性血小板减少症组(25例),选择100例健康人作为对照组。用KX-21型血细胞分析仪测定各组静脉血的血小板总数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)及血小板分布宽度(PDW),分析各组间PLT、MPV、PCT、PDW的变化。结果骨髓性血小板减少症患者PLT、PCT均低于对照组,t值分别为32.787、35.858,P值均为0.000,MPV和PDW则差异无统计学意义,t值(P值)分别为1.080(0.282)、0.664(0.508);非骨髓性血小板减少症患者PLT、PCT均低于对照组,t值分别为24.296、5.820,P值均为0.000,而MPV和PDW高于对照组,t值分别为9.842、22.666,P值均为0.000;骨髓性血小板减少症患者MPV和PCT低于非骨髓性血小板减少患者,t值分别为6.297、2.217,P值分别为0.000、0.030。结论血小板减少症患者MPV正常时提示可能为骨髓性疾病引起,MPV增大提示可能为非骨髓性疾病引起。
Objective To investigate the change of platelet parameters and its clinical significance in marrow and non-marrow thrombocytopenia （TP） patients.Methods Platelet count （PLT）,mean platelet volume （MPV）,plateletcrit （PCT） and platelet distribution width （PDW） of 53 marrow TP patients （group A）,25 non-marrow TP patients （group B） and 100 healthy individuals （the control group） were respectively determined by KX-21 blood cell analyzer,and then the changes of PLT,MPV,PCT and PDW were analyzed in the three groups.Results Compared with the control group,PLT and PCT of group A are lower （t values were 32.787 and 35.858,respectively and the P values were both 0.000）.MPV and PDW showed no statistically significant difference between the control group and group A,with t values （P values）=1.080 （0.282） and 0.664 （0.508）,respectively.Compared with the control group,PLT and PCT of group B are lower （t values were 24.296 and 5.820,respectively,and P values were both 0.000）.MPV and PDW of group B were higher than that of the control group,with t values of 9.842 and 22.666,respectively and P values both of 0.000.MPV and PCT of the group A were lower than that of group B,with t values of 6.297 and 2.217,respectively and P values of 0.000 and 0.030,respectively.Conclusion For thrombocytopenia patients,if the MPV is normal,thrombocytopenia might be caused by bone marrow diseases;if MPV is higher than the normal value,thrombocytopenia might be caused by non-marrow diseases.
出处
《海南医学》
CAS
2012年第9期97-98,共2页
Hainan Medical Journal
