摘要
目的 搜寻中国汉族人X染色体上的心境障碍 (MD)易患性基因 ,探讨DNADXS1113多态性与MD的关系及遗传学特征。方法 运用扩增片段长度多态性 (Amp FLP)检测技术 ,分析 80例MD患者DXS1113二核苷酸串联重复序的多态性分布 ,并以 80名正常人作为对照。结果 在对照组和MD组中检出 12种DXS1113多态性片段 ,MD组与对照组之间有 4种片段 (15 8bp、16 8bp、170bp、174bp)的差异有显著性 (P <0 0 5 )。结论 DXS1113与MD关联 ,提示中国汉族人X染色体长臂(Xq2 7 3 q2 8)可能存在MD易患性基因。
Objective Search for a gene predisposing to mood disorders (MD)on chromosome X in the Han nationality of Chinese, to explore the relationship between DXS1113 polymorphism with MD and feature of the genetics Methods The dinucleotide repeat polymorphism distribution of DXS1113 for 80 patients with MD was examined by amplified fragment length polymorphism (Amp FLP) examination technique The control group consisted of 80 unrelated normal Chinese individuals Results There was 12 alleles of DXS1113 among the patient and the normal controls The results of statistical handing showed that four alleles (158 bp, 168 bp, 170 bp, 174 bp) was significant different ( P <0 05) between patient and normal scontrols Conclusion The results of this study demonstrate that the DXS1113 is association with affective disorder in the Hna nationality of Chinese This results suggest that there was a mood disorders liability gene on X chromosome (Xq27 3 q28) in Chinese samples
出处
《中华精神科杂志》
CAS
CSCD
2000年第1期9-12,共4页
Chinese Journal of Psychiatry
关键词
DNA
微卫星
DXS1113
情感障碍
基因多态性
DNA,satellite
Polymorphism, amplified fragment length
Affective disorders,psychotic
