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CIP2A相关分子生物学机制的研究进展 被引量：6

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摘要 蛋白磷酸酶2A的癌性抑制因子(CIP2A)近来被鉴定与多种恶性肿瘤的发生和发展密切相关。研究表明CIP2A可以通过稳定c-Myc、促进细胞增殖和锚定独立生长、阻滞衰老和分化来促进体内恶性肿瘤的发生和发展。另外CIP2A被发现与肿瘤患者生存率和侵袭力密切相关。近年来,CIP2A转录调节和信号转导通路调节等方面的新发现极大地丰富了CIP2A的作用和调节机制。
作者 王刚刚 李玉瑭 宋坤尧 周亚滨
机构地区 山东大学医学院病原生物学研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第2期141-144,共4页 Progress in Physiological Sciences
关键词 蛋白磷酸酶2A的癌性抑制因子 抑癌作用 分子机制
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1钱安平,辛彦,肖玉平.CIP2A与肿瘤关系的研究进展[J].世界华人消化杂志,2009,17(26):2700-2704. 被引量：29
  • 2Khanna A,Okkeri J,Bilgen T,et al.ETS1 mediatesMEK1/2-dependent overexpression of cancerous inhibitor ofprotein phosphatase 2A(CIP2A)in human cancer cells.PLoS One,2011,6:e17979.
  • 3Khanna A,Bockelman C,Hemmes A,et al.MYC-depend-ent regulation and prognostic role of CIP2A in gastric canc-er.J Natl Cancer Inst,2009,101:793-805.
  • 4Chen KF,Liu CY,Lin YC,et al.CIP2A mediates effectsof bortezomib on phospho-Akt and apoptosis in hepatocellularcarcinoma cells.Oncogene,2010,29:6257-6266.
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  • 6Zhao D,Liu Z,Ding J,et al.Helicobacter pylori CagA up-regulation of CIP2A is dependent on the Src and MEK/ERKpathways.J Med Microbiol,2010,59:259-265.
  • 7Wei GH,Badis G,Berger MF,et al.Genome-wide analysisof ETS-family DNA-binding in vitro and in vivo.EMBO J,2010,29:2147-2160.
  • 8Junttila MR,Westermarck J.Mechanisms of MYC stabiliza-tion in human malignancies.Cell Cycle,2008,7:592-596.
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二级参考文献30

  • 1Mumby M. PP2A: unveiling a reluctant tumor suppressor. Cell 2007; 130:21-24.
  • 2Janssens v, Goris J, Van Hoof C. PP2A: the expected tumor suppressor. Curr Opin Genet Dev 2005; 15: 34-41.
  • 3Junttila MR, Puustinen P, Niemela M, Ahola R, Arnold H, Bottzauw T, Ala-aho R, Nielsen C,Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grenman R, Kast J, Kallunki T, Sears R, Kahari VM, Westermarck J. CIP2A inhibits PP2A in human malignancies. Cell 2007; 130:51-62.
  • 4Nagase T, Kikuno R, Ohara O. Prediction of the coding sequences of unidentified human genes. ⅩⅫ. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res 2001; 8:319-327.
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  • 8Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability. Mol Cell 1999; 3: 169-179.
  • 9Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000; 14:2501-2514.
  • 10Arnold HK, Sears RC. Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation. Mol Cell Biol 2006; 26:2832-2844.

共引文献28

同被引文献82

  • 1顾海风,夏国伟.CIP2A在恶性肿瘤中的表达及作用的研究进展[J].中华临床医师杂志（电子版）,2011,5(12):3560-3563. 被引量：8
  • 2杨安强,郑兴征,潘晓琳,付锦艳.细胞周期调控基因p21^(WAF1/CIP1)与肿瘤的关系[J].现代肿瘤医学,2006,14(2):243-245. 被引量：14
  • 3翁丹卉,邢辉,邓友星,梁逢奇,黄磊,李芳,马丁,卢运萍.短发卡状RNA抑制AKT2基因表达增强卵巢癌细胞对紫杉醇敏感性的研究[J].中华肿瘤防治杂志,2007,14(14):1041-1045. 被引量：4
  • 4Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med, 2005,352:476-487.
  • 5Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin, 2009,59 : 225-249.
  • 6Nagase T, Kikuno R, Ohara O. Prediction of the coding sequences of unidentified human genes. ⅩⅫ. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res, 2001,8 : 319-327.
  • 7Junttila MR, Puustinen P, Niemela M, et al. CIP2A inhibits PP2A in human malignancies. Cell, 2007,130 : 51-62.
  • 8Mumby M. PP2A: unveiling a reluctant tumor suppressor. Cell, 2007,130 : 21-24.
  • 9Junttila MR, Westermarck J. Mechanisms of MYC stabilization in human malignancies. Cell Cycle, 2008,7 : 592-596.
  • 10Li W, Ge Z, Liu C, et al. CIP2A is overexpressed in gastric cancer and its depletion leads to impaired elonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res, 2008,14 : 3722-3728.

引证文献6

二级引证文献17

生理科学进展
2012年 第2期

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