摘要
研究了阿尔茨海默病 (Alzheimer′sdisease ,AD)和血管性痴呆 (vasculardementia ,VD)患者脑脊液中淀粉样蛋白(Aβ1-4 2 )的含量并探讨其意义。采用酶联免疫吸附法检测 2 4例AD患者、 14例VD患者及 30例正常对照者脑脊液中Aβ1-4 2的浓度。结果AD患者和VD患者脑脊液中Aβ1-4 2 水平明显低于正常对照组。Aβ1-4 2 值用于诊断老年期痴呆 ,具有一定的特异性和敏感性 。
To detect the levels of β amyloid protein(Aβ)in cerebrospinal fluid(CSF)of patients with Alzheimer′s disease(AD)and vascular dementia(VD).The CSF levels of Aβ 1—42 in 24 patients with AD,14 patients with VD and 30 normal controls(NC)were analyzed by enzymelinked immunosorbent assays(ELISA).The data suggest significantly decreased levels of CSF Aβ 1—42 in AD and VD patients.Conclusion:AD and VD groups had significantly decreased levels of Aβ 1—42 compared with NC group.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2000年第1期4-5,共2页
Chinese Journal of Clinical Laboratory Science
