摘要
目的:观察运动再学习疗法对脑缺血损伤后恒河猴脑血流量的影响。方法:通过电凝法阻断恒河猴右侧大脑中动脉M1段制备成脑缺血损伤模型,术后采用觉醒意识水平肌力训练、协调能力及任务定向训练等运动再学习疗法(MRP),单光子发射计算机体层摄影(SPECT)测定训练前后相关脑区脑血流量的变化。结果:MRP明显改善脑缺血损伤恒河猴的局部脑血流量,但不能改变脑缺血所致的右/左脑区脑血流量的不对称性。结论:MRP可以增加脑缺血损伤周围及相关脑区脑血流量,促进受损神经功能恢复。
Objective： To observe the effect of motor relearning program（MRP） on regional cerebral blood flow（rCBF） of rhesus monkeys with cerebral ischemic stroke.Methods： Rhesus monkeys subject to an occlusion of the M1 segment of the right middle cerebral artery（MCA） by using electrocoagulation were trained with MRP,and single-photon emission computed tomography（SPECT） was used before and after MCA occlusion to semi-quantify the changes of rCBF.Results： MRP could greatly improve rCBF of the animals with cerebral ischemic stroke,but couldn＇t change the functional asymmetry of cerebral hemispheres.Conclusion： It is possible that MRP increases cerebral blood flow in injured areas and other related areas to have a significant improvement on neurological deficits caused by cerebral ischemia.
出处
《中国康复》
2012年第2期83-85,共3页
Chinese Journal of Rehabilitation
基金
云南省科技厅-昆明医学院联合专项基金资助项目(2008CD37R)
关键词
运动再学习疗法
恒河猴
脑缺血
脑血流量
motor relearning program
rhesus monkeys
cerebral ischemia
regional cerebral blood flow
