摘要
目的 分析应用口服大剂量强的松治疗急性视神经炎(AON)的疗效。方法 回顾性分析了26例(29只眼)AON患者的临床资料。结果 治疗后所有病人视力迅速增加,稳步提高。随访6个月以上的26例(29只眼)视力均≥0.8,其中93.1%视力≥1.0。大多数病人瞳孔、视乳头、视野、PVEP显著改善或恢复正常。结论 口服大剂量强的松是治疗AON合理而有效的方案;并对PVEP中P100潜伏期延长的意义及对AON的诊断进行讨论。
ObjectiveTo evaluate the efficacy of high dose prednisone on the treatment of patients with acute optic neuritis (AON).MethodsClinical case review of 26 patients(29 eyes) with acute optic neuritis treated with oral prednisone were reviewed.The visual acuity of these patients was severely impaired.6 patients were treated elsewhere with glucocorticoid.All of them were positive for relative afferent pupillary defect (RAPD).Visual field defects were compatible with optic neuritis and delay of P 100 latency in pattern visual evoked potential (PVEP) were also found.The optic discs of 16 patients were abnormal.Oral prednisone was used,starting from 100～200*!mg daily,followed by tapering the dosage by 20～40*!mg every 3*!d until 40*!mg/d.ResultsThe visual acuity of patients improved rapidly and steadily.4d after treatment the visual acuity was≥0.2 in 69% of the eyes.on d*!15,the visual acuity was≥0.6 in 65.5% of the eyes.After follow up for 6 months,the visual acuity of 26 cases(29eyes) was*!≥0.8,including 27*!eyes(93.1%)*!≥1.0.After follow up for 1*!year,the visual acuity of 19 of 20 eyes(95%)was*!≥ 1.0 .The pupil,optic disc,visual field and PVEP in most patients were improved or became normal.ConclusionThe results suggest that the regimen of high dose oral prednisone for AON is feasible and satisfactory.The role of the delay of P 100 latency in the diagnosis of AON is discussed.PVEP was a sensitive and credible sign for evaluating the extent of demyelination.
出处
《眼科研究》
CSCD
2000年第1期51-53,共3页
Chinese Ophthalmic Research
