摘要
目的探讨低分子肝素(LMWH)对预防髋、膝关节术后下肢深静脉血栓(DVT)的有效性和安全性。方法将52例行髋、膝关节手术的患者随机分为治疗组和对照组各26例。对照组不予任何抗凝药物,术后24h开始行物理方法预防DVT;治疗组在对照组治疗基础上于术前12h、术后给予LMWH腹部皮下注射,2组均治疗7d。观察并比较2组术后双下肢DVT和不良反应发生情况及血常规指标。结果治疗组治疗后DVT发生率为3.8%,低于对照组的26.9%,差异有显著统计学意义(P<0.05)。2组患者血小板计数(PLT)、血红蛋白(Hb)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及不良反应发生率比较差异均无统计学意义(P>0.05)。结论应用LMWH预防髋、膝关节术后DVT疗效确切,对凝血机制无影响,安全性好,值得临床推广应用。
Objective To explore the efficacy and safety of low molecular weight heparin(LMWH) for the prevention of hip,knee postoperative deep vein thrombosis(DVT).Methods 52 hip and knee surgery patients were randomly divided into two groups treatment group and control group with 26 in each.Without any anticoagulant medication,the control group only had physical methods to prevent DVT 24h postoperation;the treatment group was given LMWH abdominal subcutaneous injection in basis of the control group.Both groups were treated with 7d.Double lower limb DVT and the occurrence of adverse reactions and routine blood indexes were observed.Results After treatment,incidence of DVT in the treatment groupthe was 3.8%,lower than that of control group(26.9%),the differences was statistically significant(P<0.05).There were no significant differences of platelet count(PLT),hemoglobin(Hb),prothrombin time(PT),activated partial thromboplastin time(APTT) and the incidence of adverse reactions between the two groups(P>0.05).Conclusion LMWH prevention of hip and knee efficacy of postoperative DVT,and no effect on the platelets,hemoglobin,coagulation mechanism,security is good,it is worth in clinical use.
出处
《临床合理用药杂志》
2012年第11期42-43,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
低分子肝素
下肢深静脉血栓
髋关节
膝关节
预防
Low molecular weight heparin
Deep venous thrombosis
Hip joint
Knee joint
Prevention
