摘要
目的:探索绿原酸是否是双黄连发挥解热作用的物质基础。方法:在给家兔静脉注入内毒素造成的发热模型上,评价绿原酸对发热家兔体温的影响。结果:绿原酸表现出退热作用,呈现明显的量效和时效关系,但起效时间较长。结论:绿原酸是双黄连发挥解热作用的物质基础。
Objective：To investigate whether chlorogenic acid is the material basis to play the role of antipyretic effect in Shuanghuanglian and other drugs.Methods：Rabit fever model was setup by the administration of endotoxin,then the effect of chlorogenic acid on the fever was studied.Results：Chlorogenic acid had antipyretic effect and it＇s antipyretic effect showed obvious relationship between dose and time.However,it had a longer onset time.Conclusion：Chlorogenic acid is the material basis to play the role of antipyretic effect in Shuanghuanglian and other drugs.
出处
《辽宁中医药大学学报》
CAS
2012年第5期229-231,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
绿原酸
内毒素
解热作用
chlorogenic acid
endotoxin
antipyretic effect
