期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微小RNA与乳腺癌细胞的增殖和转移 被引量：5

MiRNA and the proliferation and metastasis of breast cancer cells
原文传递
导出
摘要 乳腺癌的发生是一个多因素参与的阶段性演进过程，微小RNA（miRNA）可通过调节肿瘤细胞的增殖、凋亡和迁移参与肿瘤发生、发展及远处浸润转移。miRNA影响乳腺癌细胞的增殖与转移机制研究将为乳腺癌的诊治提供新的思路。 The tumorigenesis of breast cancer is a multistep process with many factors. The microRNAs （miRNA） participates in the development and distance metastasis of tumor by regulating proliferation, apoptosis and migration of tumor cells. The study of the mechanisms that miRNA impacting breast cancer cell proliferation and metastasis may provide new ideas for the diagnosis and treatment of breast cancer.
作者 陈晓兰 秦树佩 杨建新
机构地区 广东药学院附属第一医院肿瘤科
出处 《国际肿瘤学杂志》 CAS 2012年第4期265-268,共4页 Journal of International Oncology
基金 中山市科技计划项目（20083A186）
关键词 微RNAS 乳腺肿瘤 细胞增殖 肿瘤转移 MicroRNAs Breast neoplasms Cell proliferation Neoplasm metastasis
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献4

二级参考文献59

  • 1Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005; 11:1753-1761.
  • 2Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524.
  • 3Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
  • 4Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr Opin Drug Discov Dev 2005, 8:557-566.
  • 5Brennecke J, Stark A, Russell R.B, Cohen SM. Principles of microRNA-target recognition. PLoS Biol.2005; 3:e85.
  • 6Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122:6-7.
  • 7Chen CZ, Li L, Lodish HF, Bartel DE MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83- 86.
  • 8Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006; 94:776-780.
  • 9Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006; 16:4-9.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.

共引文献266

同被引文献33

  • 1孙燕.抗癌药急性及亚急性毒性反应分度标准(WHO标准).癌症,1992,11(3):24-24.
  • 2Jeevan R, Cromwell DA, Trivella M, et al. Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospec- tive study of hospital episode statistics. BMJ, 2012, 345 :e4505.
  • 3Karachaliou N, Kouroussis Ch, Papakotoulas P, et al. A multicenter phase II trial of docetaxel plus gemeitabine as salvage treatment in anthra- cycline- and taxane-pretreated patients with metastatic breast cancer. Cancer Chemother Pharmacol, 2012, 69(5) :1345-1352.
  • 4Rasmussen F. RECIST and targeted therapy. Acta Radial, 2009, 50(8) :835-836.
  • 5DeSantis C, Jemal A, Ward E, et al. Temporal trends in breast cancer mortality by state and race. Cancer Causes Control, 2008, 19 ( 5 ) : 537- .545.
  • 6Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers[ J]. Nature, 2005, 435: 834- 838.
  • 7Sinner D, Kordich JJ, Spence JR, et al. Soxl7 and Sox4 differen- tially regulate catenin/T - cell factor activity and proliferation of co- lon carcinoma cells [ J ]. Mol Cellular Biot, 2007, 27 : 7802 - 7815.
  • 8Bosch M, Palsson- Mcdermott E, Johnson DS, et al. Lps induces the degradation of programmed cell death protein 4 ( PDCD4 ) to re- lease twist 2, activating e - Maf transcription to promote interleukin - 10production[ J]. J BioU Chem, 2014, 289 : 22980 - 22990.
  • 9Liao WT, Ye YP, Zhang N J, et al. MicroRNA - 30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2 [ J ]. J Pathol, 2014, 232 : 415 - 427.
  • 10Shuomin Zhu,Hailong Wu,Fangting Wu,Daotai Nie,Shijie Sheng,Yin-Yuan Mo.MicroRNA-21 targets tumor suppressor genes in invasion and metastasis[J].Cell Research,2008,18(3):350-359. 被引量：210

引证文献5

二级引证文献13

国际肿瘤学杂志
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部