摘要
目的探讨化疗期间给予急性白血病患者肠外营养对其免疫功能的影响。方法 40例急性白血病化疗患者随机分成对照组和治疗组,每组20例,均采用HAC方案(高三尖杉酯碱+阿糖胞苷+环磷酰胺)化疗,治疗组患者化疗同时给予肠外营养支持,对照组患者常规进食,化疗后利用流式细胞术检测患者外周血淋巴细胞亚群(CD3+、CD4+、CD8+、自然杀伤细胞)的百分率及CD4+/CD8+的水平,并比较两组患者体重和血红蛋白水平减少量的差异。结果化疗后两组患者体重、血红蛋白水平均下降,两组化疗后第一周体重和血红蛋白水平的减少量未见显著性差异,但治疗组化疗后第二周、第三周和第四周体重和血红蛋白水平的减少量均显著低于对照组(P<0.05);对照组和化疗组之间CD3+、CD8+T淋巴细胞及NK细胞的百分率无显著性差异(P>0.05),但治疗组CD4+T淋巴细胞百分率和CD4+/CD8+比率均显著高于对照组(P<0.05)。结论急性白血病患者在化疗期间予以肠外营养可以改善其全身营养状况和免疫功能,并减轻化疗药物的毒副反应。
Objective To study the effects of parenteral nutrition（PN）applied during chemotherapy on the immune function of patients with acute leukemia.Method 40 patients with acute leukemia were randomly divided into the treatment group and the control group,20 cases in each group,all the patients were treated with HAC programm e（homoharringtonine ＋cytarabine＋cyclophosphamide）,the treatment group was given PN support at the same time,the control group was given normal diet,The percentage of lymphocyte subpopulations（CD3＋,CD4＋,CD8＋,natural killer（NK）cells）and the ratio of CD4＋/CD8＋ in peripheral blood were detected by flow cytometry,the decrease of weight and the level of hemoglobin were compared between the two groups.Results The weight and the level of hemoglobin of the two groups were both decreased after chemotherapy,there was no difference of the weight lost and the decrease of hemoglobin between the two groups at the first week after chemotherapy（P0.05）;but the decrease of the weight and the level of hemoglobin in the treatment group were both lower than the control group at the second,third and fourth week after chemotherapy（P0.05）;No significant difference was observed in the percentages of CD3＋,CD8＋ and NK cells（P0.05）,but the percentage of CD4＋ and the ratio of CD4＋/CD8＋ in the treatment group were significantly higher than the control group（P0.05）.Conclusions PN applied during chemotherapy on the patients with acute leukemia was able to improve their whole body nutrition and immune function,relieve the adverse reactions of chemotherapy.
出处
《肿瘤药学》
CAS
2011年第6期530-532,共3页
Anti-Tumor Pharmacy
关键词
急性白血病
肠外营养
化疗
临床效果
Acute leukemia
Parenteral nutrition
Chemotherapy
Clinical effect
