摘要
目的对初发2型糖尿病患者进行早期的强化治疗,并探讨改善B细胞功能的可能机制。方法选择50例患者使用胰岛素泵治疗,并与口服降糖药物治疗的50例患者做比较,观察两组患者治疗后空腹血糖、胰岛B细胞功能指数、胰岛素抵抗指数(Homa-IR)以及空腹C肽水平的变化。结果治疗后两组患者空腹血糖均值均恢复到正常范围,且差异无统计学意义(P>0.05),观察组Homa-β和糖化血红蛋白比值显著优于对照组(P<0.05),两组Homa-IR间差异无统计学意义(P>0.05),观察组空腹C肽水平高于对照组(P<0.05)。结论高糖毒性的解除和胰岛细胞休息学说在2型糖尿病的发生发展中均占据重要地位。
Objective To investigate type 2 diabetes mellitus insulin or oral hypoglycemic agents treatment on beta cell function.Methods Fifty cases used insulin pump therapy and compared with oral hypoglycemic drugs in 50 patients,two groups of patients after treatment of fasting blood glucose,pancreatic islet beta cell function index,insulin resistance index（Homa-IR） and fasting C peptide level changes were observed.Results After treatment,the mean fasting blood glucose returned to normal range had no statistically significance in two groups（P 0.05）,observation group of Homa beta and glycosylated hemoglobin were significantly better than that of control group（P 0.05）,Homa-IR in the two groups had no significant difference（P 0.05）,observation group of fasting C peptide level was higher than that of control group（P 0.05）.Conclusion High glucose toxicity to lift and islet cell rest theory in the pathogenesis of type 2 diabetes mellitus in both occupy have all important position.
出处
《中国当代医药》
2012年第12期47-48,共2页
China Modern Medicine
关键词
初发2型糖尿病
胰岛素
胰岛B细胞功能
研究
Newly-diagnosed type 2 diabetes
Insulin
Pancreatic islet beta cell function
Study
