摘要
植物化学物的生物学功能研究是食品科学的研究热点之一,来源于十字花科的2-苯乙基异硫氰酸酯和l-异硫氰酸-4-甲磺酰基丁烷因具有抗癌功能而倍受关注。该两种异硫氰酸酯能影响细胞Ⅰ相和Ⅱ相酶活性、激活Nrf2-Keap1系统、抑制细胞核因子κb及促进肿瘤细胞凋亡,起到预防癌症的作用。文章综述近年来两种异硫氰酸酯抗肿瘤机制的研究进展及应用前景,为合理开发十字花科植物保健价值提供参考。
The biological function of phytochemicals has became one of the hottest research areas on food science.For the cancer chemoprevention,isothiocyanates 2-Phennethyl（PEITC） and 4-Methylsulfinylbuty（SFN） from the crucifers were widely investigated.These anti-cancer activities have been attributed to a variety of physiological actions including inducing phaseⅠand phaseⅡenzymes,activating Nrf2-Keap1 system,inhibiting the transcription factor κ b and promoting cell apoptosis.Their molecular mechanisms of chemoprevention effects and perspectives were reviewed in this paper which amid to provide reference for the cruciferaes resource development.
出处
《食品与机械》
CSCD
北大核心
2012年第2期241-244,共4页
Food and Machinery
