摘要
肺癌细胞对化疗药物产生耐药性是目前肺癌化疗过程中遇到的主要问题。微小RNA(miRNA)是一类内源性非编码短链小分子RNA,它能调节细胞生长、凋亡和信号转导。miRNA的多态性与药物代谢和耐药形成密切相关,异常表达的miRNA对预测肺癌化疗药物敏感性有重要作用。调节特异miRNA的表达,将为克服肺癌耐药和选择个体化治疗开辟新的途径。
Drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue aurlng the chemotherapy of lung cancer. MicroRNAs （miRNAs） are a class of endogenetic, non-coding, short-chain and small RNAs that regulate cell growth, apoptosis and signaling transduction, miRNA polymorphisms associte with drug metabolsim and drug resistance formation. Moreover, differentially expressed miRNAs play critical roles in prediction of the sensitivity to chemotherapeutic agents in lung cancer. Regulation of specific miRNA expression will break a new path for overcoming lung cancer resistance and the personalized therapy.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2012年第4期391-397,共7页
Chinese Journal of Cell Biology
基金
浙江省教育厅重点项目(No.Z201119414)
宁波市科技创新团队项目(No.2011B82014)
宁波大学王宽诚教育基金资助项目~~
关键词
微小RNA
多态性
肺癌
化疗耐药
个体化治疗
microRNA
polymorphism
lung cancer
chemoresistance
personalized therapy
