摘要
microRNA(miRNA)是在多种真核细胞和病毒中发现的一类内源性非编码单链RNA,长约22个核苷酸,在进化上具有高度的保守性。miRNA可以通过碱基互补与靶基因mRNA的特定位点结合,抑制该蛋白合成或诱导该mRNA降解,在生物体生长、发育和疾病发生等过程中发挥着重要的作用。我们简要叙述了miRNA的特点和作用机制,并对miRNA在基因表达调控、胚胎干细胞调控及免疫调节等方面的最新进展进行了综述。
microRNA（miRNA） are endogenous non-protein-coding RNA of approximately 22 nucleotides.Thousands of miRNA genes have been identified in a variety of organisms,which suggests that miRNA genes have been widely shared and distributed among species.miRNA can negatively regulate gene expression by complementary binding to the 3’-UTR regions of their target genes and play an important role in growth,development and occurrence of disease.In this paper,the characteristics and the active mechanism of miRNA,and the recent progress in the research on the function of microRNA were summarized
出处
《生物技术通讯》
CAS
2011年第1期98-103,共6页
Letters in Biotechnology
基金
国家高技术研究发展计划(2008AA10Z140)
国家自然科学基金项目(30571339)
转基因生物新品种培育科技重大专项(2009ZX08008-004B
2008ZX08008-003)
中国农业科学院创新基金(2004-院-1)
