摘要
在0.40 mol/L的HAc-NaAc(pH=4.8)缓冲溶液中,卡托普利(Captopril,CPT)在碳糊电极(CPE)上有一灵敏的吸附氧化峰,峰电位为0.23 V(vs.SCE)。该氧化峰的二阶导数峰电流与卡托普利的浓度在2.0×10-8～1.0×10-6mol/L(富集90 s)范围内呈良好的线性关系,相关系数为0.9966,检出限为8.0×10-9mol/L,并成功应用于卡托普利片含量的测定。探讨了卡托普利在碳糊电极上的伏安性质和电极反应机理。
A highly selective and rapid anodic adsorptive voltammetric method has been developed for the determination of trace amount of captopril at a carbon paste electrode（CPE）in the current paper.Captopril is adsorbed on the surface of the CPE in 0.40 mol/L HAc-NaAc buffer solution（pH=4.8）,yielding one oxidation peak at 0.23 V（vs.SCE）.The relationship between the peak current and captopril concentration is linear in the range of 2.0×10-8~1.0×10-6 mol/L with the correlation coefficient of 0.9966.The detection limit is 8.0×10-9 mol/L（S/N=3） for 90 s acummulation.The proposed method was applied to the direct determination of captopril in the captopril tablet with satisfactory results and the electrode reaction mechanism of captopril was investigated.
出处
《分析科学学报》
CAS
CSCD
北大核心
2012年第2期230-232,共3页
Journal of Analytical Science
基金
湖南省科技计划(No.2010GK3181)
湘潭大学自然科学基金(No.10XZX07)
湖南省大学生创新性实验计划资助项目
关键词
卡托普利
阳极吸附伏安法
碳糊电极
Captopril
Anodic adsorption voltammetry
Carbon paste electrode
