摘要
建立卡托普利片的含量测定HPLC方法。色谱柱：Kromasil C18；流动相：0．05％磷酸溶液-甲醇-四氢呋喃（42：52：6）（用三乙胺调节pH至3．0±0．05）；检测波长：215nm，流速：1．0mL·min^-1；柱温：30℃。卡托普利线性范围为5．08-254．01μg·mL^-1，r=0．9999，平均回收率为99．94％，RSD为0．29％（n=9）。方法可靠，简单可行，为控制卡托普利片的内在质量提供了科学依据。
To establish a method for determination the content of Captopril Tablets by Kromasil C18 column was used with mixture of 0. 05% solution of phosphoric acid- HPLC. The methanol -- tetrahydrofuran （42 ： 52 ： 6, adjust to pH 3.0 ± 0. 05 with triethylamine） as the mobile phase . The detection wavelength set at 215nm and the flow rate was 1.0mL · min ^-l. The temperature of the column maintained at 30 ℃. The linear range of Captopril was 5.08- 254.01μg · mL^-1 and the average recovery was 99.94% （RSD=0.29%, n=9）. The method is simple andreliable. It can be applied to the quality control of the Captopril Tablets.
出处
《中国药事》
CAS
2008年第5期409-410,共2页
Chinese Pharmaceutical Affairs
