摘要
目的分析全身DWI（WB—DWI）上的骨髓正常表现及其影响因素。方法对98名健康志愿者（男47名，女51名）进行WB—DWI扫描，测量胸椎、腰椎、双侧股骨（头、颈、上段、远端）、髂骨、肱骨头、肩胛骨的ADC值、DWI（b=800s／mm2）及STIR信号值。采用秩相关性检验分析骨髓DWI信号值与ADC值及STIR信号值的关系，不同部位骨髓ADC值比较采用ANOVA法，两两比较采用Student-Newman—Keuls检验，男女不同部位骨髓ADC值与年龄的相关性分析采用秩相关检验。结果（1）98名志愿者中，69名骨髓呈低至中等信号，其中女24名、男45名；29名骨髓呈高信号，其中女27名、男2名。（2）胸椎、腰椎、股骨头、股骨颈、股骨上段、髂骨、肱骨头、肩胛骨骨髓DWI信号值（M值分别为44．54、35．01、13．61、16．00、21．45、25．77、18．35、36．12）与ADC值[（0．55±0．08）×10-3、（0．53±0．08）×10-3、（0．30±0．10）×10-3、（0．42±0．16）×10-3、（0．74±0．14）×10-3、（0．49±0．10）×10-3、（0．36±0．13）×10-3、（0．49±0．11）×10-3mm2／s]及STIR信号值（肘值分别为61．81、64．99、53．27、69．08、73．10、66．35、73．16、79．81）呈正相关，r值分别为0．513、0．695，0．741、0．764，0．443、0．489，0．641、0．656，0．510、0．648，0．475、0．715，0．366、0．446，0．437、0．739，P值均〈0．01。（3）不同部位骨髓ADC值差异有统计学意义（F=138．69，P〈0．01）。胸椎与腰椎、髂骨与肩胛骨，股骨头与股骨远端之间差异无统计学意义（P值均〉0．05），其余任意两组差异均有统计学意义（P值均〈0．05）。（4）女性胸椎[（0．59±0．07）×10-3mm2／s]、腰椎[（0．58±0．06）×10-3mm2／s]、股骨头（肘值0．33×10-3mm2／s）、股骨颈（M值0．53×10-3mm2／s）、股骨上段（M值0．81×10-3mm2／s）、股骨远端（M值0．32×10-3mm2／s）、髂骨[（0．52±0．09）×10-3mm2／s]、肱骨头（M值0．42×10-3mm2／s）、肩胛骨[（0．53±0．09）×10-3mm2／s]骨髓ADC值均高于男性[（0．51±0．07）×10-3、（0．48±0．07）×10-3、M值0．23×10-3、M值0．31×10-3、M值0．66×10-3、M值0．23×10-3、（O．46±0．10）×10-3、M值0．27×10-3、（0．45±0．11）×10-3mm2／s]。（5）女性胸椎、腰椎、股骨（头、颈、上段）、髂骨、肱骨头骨髓ADC值与年龄呈负相关（r值分别为-0．549、-0．629、-0．329、-0．524、-0．338、-0．548和-0．416，P值均〈0．05），而女性股骨远端、肩胛骨和男性各部位骨髓ADC值与年龄无明显相关性（P值均〉0．05）。结论骨髓ADC值及STIR信号值越高，其DWI（b=800s／mm2）信号值越高；骨髓ADC值受年龄和性别影响，不同部位骨髓ADC值不同。
Objective weighted imaging （WB-DWI） To analyze the pattern of normal and its influence factors. Methods bone marrow on whole body diffusionA total of 98 healthy volunteers （male 47 and female 51 ）. All volunteers underwent WB-DWI at 1.5 T MR scan. The ADC value, the signal intensity on DWI obtained with a b value of 800 s/mm2 （SIDWT）, and the signal intensity on short time inversion recovery images （ SISTIR ） of thoracic vertebrae, lumber vertebrae, bilateral head of femur, bilateral neck of femur, bilateral superior segment of femur, bilateral inferior segment of femur, bilateral ilium, bilateral head of humerus, bilateral scapula were measured and compared with ANOVA test and StudentNewman-Keuls test. The normal appearance of bone marrow on WB-DWI was assessed. The relationship between the SIDWl and the ADC, and the SIDWI and the SIsnR of bone marrow were analyzed. The ADC of bone marrow between male and female were compared. Spearman correlation analysis was performed for different age groups. Results （ 1 ） Bone marrow signal intensity was different among 98 healthy volunteers. Bone marrow in 69 healthy volunteers （female 24, male 45） showed low to intermediate signal intensity, whereas in the remaining 29 healthy volunteers （female 27, male 2） showed high signal intensity. （2） The SIDWI of thoracic vertebrae （median 44. 54）, lumber vertebrae （median 35.01 ）, head of femur （ median 13.61 ） , neck of femur （ median 16.00） , superior segment of femur （ median 21.45 ） , ilium （ median 25.77）, head of humerus （ median 18.35 ）, scapula （ median 36. 12） was positively correlated with the ADC [（0.55±0.08）×10-3, （0.53±0.08） ×10-3, （0.30±0.10） ×10-3, （0.42±0.16） ×10-3, （0.74±0.14） ×10-3, （0.49±0.10） x10-3, （0.36±0.13） ×10-3, （0.49±0.11） ×10-3mm2/s] and the SISTIR （median 61.81, 64.99, 53.27, 69.08, 73.10, 66.35, 73.16, 79.81）, r =0.513 and 0.695, 0.741 and 0.764, 0.443 and 0.489, 0.641 and 0.656, 0.510 and 0.648, 0.475 and 0.715, 0. 366 and 0. 446, 0. 437 and 0. 739;P 〈0. 01. （3） There was significant difference of the ADC of bone marrow in different bone, F = 138.69, P 〈 0. 01. Student-Newman-Keuls test revealed that no significant difference was found in the ADC between thoracic vertebrae and lumbar vertebrae, ilium and scapula, head of humerus and inferior segment of femur （P 〉 0. 05 ）, and significant difference was found in the ADC values between the remaining two groups （ P 〈 0. 05 ）. The bones associated with decreasing ADC values were superior segment of femur, thoracic vertebrae and lumber vertebrae, ilium and scapula, neck of femur, head of humerus, head of femur and inferior segment of femur. （ 4 ） The ADC values of bone marrow of female subjects in thoracic vertebrae [ （0. 59 ±0. 07） ×10-3 mm2/s ],lumber vertebrae [ （0. 58 ±0. 06） ×10-3 mm2/s] ,head of femur （median 0. 33 ×10-3 mm2/s） , neck of femur （median 0. 53 ×10-3 mm2/s） , superior segment of femur （ median 0. 81 × 10 -3 mm2/s ） , inferior segment of femur （ median 0. 32 ×10 -3 mm2/s）, ilium [ （0. 52 ±0. 09） × 10 -3 mm2/s], head of humerus （ median 0. 42 ×10 -3 mme/s）, scapula [ （0. 53 ± 0.09 ） ×10-3 mm2/s × were significantly higher than those of male subjects × （0. 51 ± 0. 07） ×10 -3, （0.48 ± 0.07） × 10-3, median 0. 23 ×10-3, median 0. 31 ×10 -3, median 0.66 × 10-3, median 0. 23 ×10 -3, （0.46 ± 0. 10 ） ×10 -3, median 0. 27 ×10 -3, （0.45 ± O. 11 ） ×10 -3 mm2/s ]. （5） There was significant negative correlation between the ADC values of bone marrow and age in thoracic vertebrae, lumber vertebrae, head of femur, neck of femur, superior segment of femur, ilium, head of humerus for female subjects, r = -0.549, -0.629, -0.329, -0.524, -0.338, -0.548 and -0.416, respectively, P 〈 0. 05. There was no significant correlation between ADC values and age in inferior segment of femur and scapula for female subjects and all the regions for male subjects （ P 〉 0. 05 ）. Conclusions The ADC and the SIsTIR of bone marrow correlates with the SIDWI. The ADC values of bone marrow is affected by age and sex, and is different for different bones.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2012年第4期340-344,共5页
Chinese Journal of Radiology
基金
基金项目：河北省卫生厅科研基金资助项目（20100091）
关键词
磁共振成像
弥散
骨髓
参考值
Diffusion magnetic resonance imaging
Bone marrow
Reference values
