摘要
背景:磁共振弥散张量可对每个体素水分子扩散的各向异性作出准确的检测。利用扩散张量成像评价肾脏及其病变内水分子运动特征,可反映出肾组织超微结构的变化,有利于病变的早期诊断。目的:验证磁共振扩散张量成像对正常肾脏和肾脏病变的临床诊断价值。方法:选择健康对照组12例和24例肾脏病变患者行肾脏扩散张量成像检查,肾脏病变患者中肾癌7例,肾囊肿7例,肾积水10例。观察肾脏皮质、髓质以及病灶表观扩散系数、分数各向异性的变化,并行髓质纤维束成像。结果与结论:正常肾脏中,肾皮质的表观扩散系数显著高于肾髓质(P=0.003),而肾髓质的分数各向异性显著高于肾皮质(P<0.05)。肾癌表观扩散系数低于正常肾皮质、髓质(P<0.05),瘤体内分数各向异性显著低于正常肾髓质(P<0.05)。肾囊肿表观扩散系数显著高于正常肾皮质、髓质(P<0.05),分数各向异性显著低于肾皮质和髓质(P<0.05)。扩散张量纤维束示踪图可重建出肾髓质纤维束的形态,从而反映出肾小管和集合管的结构变化。提示扩散张量成像能显示正常肾脏和肾脏病变的超微结构变化,可用于肾脏病变的早期诊断和病情监控。
BACKGROUND：Diffusion tensor can accurately detect diffusion anisotropy of water in each voxel,which can reflect changes in the ultrastructure of normal or abnormal kidney tissue and is beneficial to early diagnosis of kidney disease.OBJECTIVE：To evaluate the clinic application of the diffusion tensor imaging（DTI） in kidney and kidney diseases.METHODS：A total of 12 healthy people and 24 patients with renal lesions underwent DTI using a 3.0T MR scanning.There were 10 cases of hydronephrosis,7 of kidney carcinoma and 7 of kidney cyst.Apparent diffusion coefficient（ADC） and fractional anisotropy（FA） values in the cortex,medulla and in lesions were calculated and analyzed retrospectively followed by medullary fiber tractography.RESULTS AND CONCLUSION：In normal kidney,ADC was significantly greater in cortex than that in medulla（P=0.03）,while medullary FA was significantly greater than cortical FA（P 0.05）.Kidney carcinoma patients exhibited lower cortical and medullary ADC but greater FA compared with the control group（P 0.05）.DTI can reconstruct appearance of renal medullary fiber bundles to reflect renal tubule and collecting duct changes.Results demonstrate that DTI can display the ultrastructural changes in normal and lesioned kidney and can be used for early diagnosis and disease monitor of renal lesions.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第43期8053-8056,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
扬州大学临床学院基金资助(yzucms0926)
课题名称:磁共振扩散张量成像早期诊断糖尿病肾病的实验研究~~
