摘要
目的测量中国正常汉族成人内囊体积，分析内囊体积与年龄、体质量及颅脑容积的相关性。方法选择健康汉族成人志愿者1000名，按照年龄18—30、31～40、41～50、51—60、61—80岁分为5组，每组男、女各100名。所有受试者均行3D磁化强度预备梯度回波序列T1WI，应用3D体积分析软件手工勾绘ROI，测量受试者内囊体积，并进行标准化处理。双侧内囊体积间比较采用配对t检验分析，不同性别间内囊体积比较用两独立样本t检验分析，不同年龄段之间内囊体积的比较采用单因素方差分析，并对内囊体积和年龄、体质量、颅脑容积的相关性做积差相关分析。结果1000名受试者左、右侧内囊体积分别为（2809±393）、（2677±343）mm3，左侧大于右侧（t=12．078，P〈0．05）。男性左、右侧内囊体积分别为（2863±396）、（2744±358）mm3，女性分别为（2754±385）、（2609±314）mm3，男性左、右侧内囊体积均大于女性（t值分别为1．982、2．851，P值均〈0．05）。5组上述不同年龄志愿者左侧内囊体积分别为（3273±361）、（2943±299）、（2777±255）、（2607±199）、（2444±213）mm3，右侧分别为（2993±361）、（2814±270）、（2682±239）、（2543±219）、（2351±210）mm3，5组间左、右侧内囊体积差异均有统计学意义（F值分别为55．244、34．493，P值均〈0．05）。左、右侧内囊体积均与年龄呈负相关（r值分别为-0．718、-0．637，P值均〈0．05）。结论1．5TMR扫描仪能明确辨别内囊的边界，精确测量内囊体积；内囊体积与年龄呈负相关。
Objective To explore the normal range of the volume of internal capsules in Chinese adults of the Han nationality and its relationship with age, body tlabitus, and craniocerebral volume. Methods One thousand healthy volunteers （age range = 18 to 80 years） were divided into 5 groups according to their age;Group A （18 to 30 years old） , group B （31 to 40 years）, group C （41 to 50 years）, group D （51 to 60 years） , and group E （61 to 80 years）. Each group consisted of 100 males and 100 females. MR imaging was performed in all of the volunteers using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. After three dimension data reconstruction, the volumes of bilateral internal capsules were manually measured. The volumes of bilateral internal capsules were compared by paired sample t test. The internal capsule volumes were compared between male and female by independent sample t test, and the differences among 5 age groups were compared by one-way ANOVA. The relationship between the volumes of internal capsule and age, body habitus or cerebral volume were analyzed using bivariate correlation. Results The left and right internal capsule volumes were （2809 ± 393） and （2677 ± 343 ） mm3 respectively. The left internal capsule volumes were significantly larger than that of right （t = 12. 078 ,P 〈 0. 05 ）. The left and right side of internal capsule volumes in male were （2863 ± 396） and （2744 ±358） mm3 respectively , and （2754±385） and （2609 ±314） mm3 in female. The left and right internal capsule volumes were larger in males than in female（ t = 1. 982,2. 851 ;P 〈 0. 05 ）. The left internal capsule volume of the 5 age groups were （3273 ±361）, （2943 ±299）, （2777 ±255）, （2607 ± 199）, （2444 ±213） mm3, and the right were （2993 ±361）, （2814 -±270） , （2682 ±239）, （2543 ±219）, （2351 ±210） mm3. There were significant differences among 5 age groups between left and right internal capsule volume （ F = 55. 244,34. 493 ; P 〈 0. 05 ）. There was significant negative correlation between the volume of left and right internal capsule and age （r = -0. 718, -0. 637;P 〈0. 05）. Conclusions 1.5 T MR scanner can be used to accurately measure the internal capsule volumes. There is a significant negative correlation between age and internal capsule volumes.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2012年第4期304-307,共4页
Chinese Journal of Radiology
基金
基金项目：国家科委863计划资助项目（2006AA02z391）
科技部973资助项目（2005CB522800,2004CB318101）
国家自然科学基金资助项目（30621004,30870697）
关键词
内囊
磁共振成像
器官测量
Internal capsule
Magnetic resonance imaging
Organ size
