摘要
从胆囊炎或胆结石病人的T管胆汁中分离出了糖蛋白。研究了含胆红素、氯化钙、胆盐和糖蛋白体系中,胆红素钙的形成。实验结果指出,在糖蛋白的作用下,胆红素钙的颗粒增大和单位体积内的颗粒数增加。用类似实验,也观察到了由黄嘌呤氧化酶/次黄嘌呤产生的超氧游离基也引起胆红素钙的聚合。因此,糖蛋白和游离基在胆结石形成过程中的作用值得进一步研究。
Glycoprotion has been separated from T tube bile of patients with gallstone and biliary inflammation. The calcium bilirubinate formation from a solution containing bilirubin, calcium chloride, bile salts and the glycoprotion, was studies to ascertain the agglomerating effect of the glycoprotion. The results indicate that the particle size and the particale number in unin volume of solution tend to increase under the influence of glycoprotein.The agglomerating effect of actived oxygen free radical has been observed in similar experiments but in the presence of xauthine oxidase/hypoxauthine which generals superoxide free radicals. In contrast, if the bilirubin is treated with free radicals generated by 'Co radiation or FeSO4/EDTA system, no such agglomerating effects were observed. Thus, the effects of glycoprotein as well as free radical are noteworthy in the course of pigment gallstone formation.
出处
《北京医科大学学报》
CSCD
1989年第3期221-223,共3页
Journal of Peking University(Health Sciences)
关键词
胆红素钙
糖蛋白
活性氧游离基
Calcium bilirubinate Glycoprotein Actived -oxygen free radical Agglomeration
