摘要
目的:评价快速静脉滴注甘露醇在预防小细胞肺癌出现脑转移中的作用。方法:37例无脑转移的局限期小细胞肺癌病人随机分为两组,治疗组20例,对照组17例。治疗组,化疗前30分快速滴注甘露醇,对照组仅予静脉化疗,观察两组患者脑转移出现的时间、频度。结果:治疗组出现脑转移的时间平均为11个月,对照组出现脑转移的时间平均为7个月。结论:甘露醇在预防小细胞肺癌出现脑转移中具有重要作用。
Objective：To evaluate the effect of rapid intravenous infusion of mannitol in prevention of brain metastases in small cell lung cancer.Methods： All 37 patients of limited small cell lung cancer without brain metastases were randomly divided into two groups,20 cases in treatment group,17 patients in control group.Rapid infusion of mannitol in treatment group 30 minutes before chemotherapy and the control group only received chemotherapy,to observe the time of brain metastases.Results： The average time of brain metastases in treatment group was 11 months,and the control group was 7 months.Conclusion： Mannitol has an important role in the prevention of brain metastases in small cell lung cancer.
出处
《现代肿瘤医学》
CAS
2012年第4期744-745,共2页
Journal of Modern Oncology
关键词
甘露醇
血脑屏障
小细胞肺癌
脑转移
mainnitol
blood brain barrier
small-cell lung cancer
brain metastasis
