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吸附介导脑内靶向递药系统的研究进展 被引量：3

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摘要 目的:综述吸附介导脑内靶向递药系统的研究进展。方法:查阅近年来有关文献,进行归纳总结。结果:吸附介导促进脑转运主要是利用递药系统表面的正电荷与血脑屏障(BBB)膜上阴离子(包括腔面侧的唾液酸和基膜侧的硫酸肝素)之间的静电作用完成的。常见的递释系统有碱性多肽、阳离子化蛋白、嵌和蛋白和阳离子蛋白结合载药系统等。结论:通过吸附介导能够有效地促进药物的脑内转运,该类递释系统对于脑部疾病的治疗具有较高的应用前景。
作者 谢月玲 蒋新国
机构地区 复旦大学药学院药剂学教研室
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2007年第2期238-240,共3页 Chinese Journal of Hospital Pharmacy
关键词 吸附介导 血脑屏障 脑内转运 阳离子蛋白 纳米粒
分类号 R944.9 [医药卫生—药剂学]
  • 相关文献

参考文献20

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二级参考文献23

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共引文献12

同被引文献102

引证文献3

二级引证文献13

中国医院药学杂志
2007年 第2期

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