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三叶因子3研究进展 被引量：7

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摘要 在生理状态下,三叶因子3(TFF3)表达于胃肠道黏膜组织及其他黏膜组织中的分泌细胞,其通过增加上皮细胞的迁移、减少上皮细胞的凋亡来促进损伤的修复和愈合。当机体发生消化系统炎症、肿瘤等病理性改变时,TFF3会伴随病理过程而发生异常表达和/或持续分泌。大量研究资料表明TFF3的异常表达与疾病发生发展及预后相关。因此,对于消化道相关疾病的实验诊断及预后判断,TFF3可能是一个潜在的临床标志物。但其具体的生理病理功能及作用机制目前还不是很明确,故其实际应用于临床还需要更加充分的、进一步的深入研究,以及更多前瞻性的临床研究资料来加以判断。
作者 周帅 符国珍
机构地区 中南大学湘雅医学院附属海口医院 海口市人民医院肝胆外科
出处 《海南医学》 CAS 2012年第8期123-125,共3页 Hainan Medical Journal
基金 海南省自然科学基金(编号:309115)
关键词 三叶因子3 肿瘤 炎症 黏膜修复/保护
分类号 R331.141 [医药卫生—人体生理学]
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参考文献24

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同被引文献111

  • 1殷胜骏,韩涛,薛新丽,尹晓娟,李宏.溃疡性结肠炎临床用药聚类分析[J].中国实验方剂学杂志,2008,14(6):77-79. 被引量：12
  • 2Jeong Soo Ahn,Chun-Sick Eom,Christie Y Jeon,Sang Min Park.Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies[J].World Journal of Gastroenterology,2013,19(16):2560-2568. 被引量：13
  • 3曾常春,王先菊,李子孺,刘汉平,郭周义,刘颂豪.激光针灸的研究及其信息模拟[J].中国临床康复,2005,9(17):175-177. 被引量：20
  • 4张姮,夏冰,杨桂芳,李瑾.溃疡性结肠炎肠黏膜组织CD8、Fas／FasL和Bcl-2／Bax的表达及关系[J].世界华人消化杂志,2006,14(18):1795-1798. 被引量：3
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  • 7Suemori S, Lynch- Devaney K, Podolsky DK. Identification and characterization of rat intestinal trefoil factor: tissue- and cell -specific member of the trefoil protein family[ J ]. Proc Natl Acad Sci U S A, 1991, 88 (24) : 11017 -11021.
  • 8Emami S, Rodrigues S, Rodrigue CM, et al. Trefoil factor family(TFF)peptides and cancer progression[J]. Peptides, 2004, 25 (5) : 885 - 898.
  • 9Hinz M, Schwegler H, Chwieralski CE, et al. Trefoil factor family(TFF) expression in the mouse brain and pituitary: changes in the developing cerebellum[ J ]. Peptides, 2004, 25 (5) : 827 - 832.
  • 10Otto WR, Thim L. Trefoil factor family -interacting proteins[ J ]. Cell Mol Life Sci, 2005, 62 (24) : 2939 -2946.

引证文献7

二级引证文献43

海南医学
2012年 第8期

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