摘要
[目的]探讨腔内放疗对鼻咽癌外照射后鼻咽腔内未消退病灶的治疗效果 ,研究近距离放疗时8个剂量参照点的剂量分布及其影响因素。[方法]1994年4月至1998年11月共对34例鼻咽癌外照射后鼻咽腔内未消退病灶行高剂量率近距离放疗(外照射剂量60Gy～71Gy,外照射结束后2天～5天进行首次治疗 ,多数病例剂量参考点深度1 0cm ,放射源驻留长度2 0cm～3 5cm ,多数病例单次剂量8Gy、总剂量16Gy/2次。[结果]CR38例(38/39,97 4 %) ,PR1例(1/39,2 6%) ,中位随访期17月 ,无严重副作用发生 ,通过计算明确了8个参照点的剂量分布情况。[结论]腔内放疗是控制鼻咽腔内外照射后未消退病灶的有效治疗方法 。
To evaluate the effect of HDR brachytherapy for residual tumor in NPC 39 patients received 60Gy～71Gy of external beam irradiation with nasopharyngeal residual lesions were treated by brachytherapy from April 1994 to November 1998 Most patients received a total dose of 16Gy/2frations The single fraction dose of most patients was 8Gy with 1 0 cm reference point The complete response was found in 38 cases(38/39,97 4%) and the partial response in 1 case(1/39,2 6%) The median follow up period was 17 monthes There was no serious side effect [Conclusion]HDR brachytherapy is a effective procedure to nasopharyngeal residual lesion of NPC following internal and external radiation But the indication for HDR farther brachytherapy should be considered strictly
