摘要
目的 :探讨DDp + 5 -Fu诱导化疗在鼻咽癌治疗中的临床意义。方法 :对 82例Ⅲ～Ⅳ期鼻咽癌患者随机分为两组 :诱导化疗组 (诱导化疗 +放疗组 ) 39例 ,对照组 (单纯放疗组 ) 4 3例。诱导化疗组在放疗前先用DF方案化疗 2个周期 ,放疗方案两组相同。结果 :诱导化疗组与对照组 1年局部控制率分别为 97 4%和 81 4% ,1年无远处转移率分别为 97 4%和 83 7% ,两组相比有显著性差异 (P <0 0 5 )。 3、5年局控率 ,无远处转移率及 1、3、5年生存率两组无显著性差异 (P >0 0 5 )。两组中的毒副反应以诱导化疗组为明显 ,但经对症处理后未影响治疗疗程。结论 :DDp + 5 -Fu诱导化疗能够提高晚期鼻咽癌的近期疗效 ,但未能提高其远期疗效。化疗与放疗如何结合应用 。
Objective: To evaluate the effect of DDP plus 5-Fu as induction chemotherapy on patients with advanced nasopharyngeal cancer (NPC). Methods: Righty-Two patients at stages Ⅲ-Ⅳ NPC were randomly divided into two groups, 39 patients received induction chemotherapy (DDP and 5-Fu) two cycles before radiation treatment (RT), 43 patients received RT alone. RT in both groups was similar. Results: One year local control rates in the group of induction chemotherapy plus RT and RT alone were 97.4% and 81.4% respectively, the differences were significant (P<0 05). Three-five years local control rates, nondistant metastasis and the 1～、2～、3～ year survival rates were found no significant difference (P>0 05). The toxic side effect of induction chemotherapy+RT group was more prominent, but it didn't affect the whole treatment course. Conclusion: DDP plus 5-Fu can only improve short-term therapeutic efficacy, therefore how to raise the long-term therapeutic efficacy is a problem to be studied.
出处
《宁夏医学院学报》
2000年第3期175-177,共3页
Journal of Ningxia Medical College
关键词
诱导化疗
鼻咽癌
综合疗法
放射疗法
induction chemotherapy
nasopharyngeal cancer
radiotherapy
