摘要
:[目的]探讨提高Ⅱ、Ⅲ期卵巢上皮癌生存率的方法。[方法]从1984年1月至1994年1月的84例Ⅱ、Ⅲ期卵巢上皮癌患者均接受了全子宫双附件大网膜切除术 ,其中36例行系统性腹膜后淋巴结清扫 ,31例行盆腔腹膜切除 ,9例行部分直肠和乙状结肠切除。所有病例均用FPM(5 Fu、DDP、MMC)方案行全身化疗和腹腔化疗。[结果]总的5年生存率为70 2%。其中Ⅱ期和Ⅲ期分别为96 3%和57 9%(P<0 001) ;肿瘤有残留者和无残留者分别是46 2%和93 3%(P<0 001);Ⅲ期病例淋巴结清扫与非清扫分别为87 5%和36 4%(P<0 001) ;Ⅲ期淋巴结转移与非转移分别为75 0%和100%(P>0 10);全身化疗≤4个疗程和全身化疗≥5个疗程者分别为3例/9例(33 3%)和56例/72例(77 8% ,P<0 001)。[结论]切净肿瘤 。
To study the methods of improving survival rate in the patients with stage Ⅱ and stage Ⅲ epithelial ovarian carcinoma Eighty four patients received combined modality therapy from Jan 1984 to Jan 1994 All patients received hysterectomy withoophorosalpingectomy and omentectomy Retroperitoneal systematic lymphadenectomy was performed in 36 cases,pelvic peritoneal resection in 31 cases,partial rectectomy in 9 cases and partial enterectomy in 4 cases All cases received intraabdominal and systematic chemotherapy with FPM(5 Fu,DDP,MMC)regimen The overall 5 year survival rate was 70 2%;The 5 year survival rates were 96 3% and 57 9% for stage Ⅱ and stage Ⅲ(P<0 001);46 2% and 93 3% for residual and no residual tumor(P<0 001);87 5% and 36 4%(P<0 001)for stage Ⅲ cases with retroperitoneal lymphadenectomy and non lymphadenectomy;75%(9/12)and 100%(12/12)(P>0 10)for stage Ⅲ cases with lymph node metastasis and nonmetastasis;3/9(33 3%)for those patients received ≤4 courses and ≥5 courses systematic chemotherapy 56/72(77 8%,P<0 001) [Conclusion]Surgery with lymphadenectomy and no residual tumor followed by FPM regimen chemotherapy more than 5 courses is effective to improve 5 year survival rate in stage Ⅲ cases with ovarian cacinoma
关键词
卵巢肿瘤
综合治疗
预后
ovarian neoplasms
comprehensive therapy
prognosis
