摘要
目的：探讨细胞减灭术及化疗对卵巢上皮性癌的治疗效果及影响因素。方法：回顾性分析１９８０年１月至１９９２年１２月在我院治疗且经细胞减灭术后肿瘤残留灶≤２ｃｍ的卵巢上皮性癌７６例的临床资料，其中，Ⅱ期２６例，Ⅲ期５０例；术后无残留灶者５２例，残留灶直径≤２ｃｍ者２４例。术后均采用ＣＡＰ方案（环磷酰胺、阿霉素、顺氯氨铂），ＡＰ方案（阿霉素、顺铂），ＣＥ方案（卡铂、表阿霉素）进行化疗。结果：总的５年生存率为３３．６％。其中，Ⅱ期为３４．９％，Ⅲ期为２９．５％（Ｐ＞０．１）。有残留灶与无残留灶者的５年生存率分别为１６．５％及３７．６％（Ｐ＜０．０５）。化疗疗程数＜８及≥８者的５年生存率分别为２０．０％及６０．１％（Ｐ＜０．００１）。结论：经细胞减灭术后，有无肿瘤残留灶和术后化疗的疗程数均与预后有关，其中化疗疗程数对生存期影响更大。
Objective:Toevaluatetheimpactofcytoreductivesurgerypluscombinedchemother-apyonadvancedovariancancer.Methods:FromJan.1980toDec.1992,76patientsadmitedtoourhospitalforprimarytreatment,wereeligibleforretrospectiveevaluation.26patientswithstageⅡand50withstageⅢ.Alpatientswithovariancancerweregivencytoreductivesurgeryfolowedbysystemicandintraabdominalchemotherapy.RegimenswereCAP(Cyclophosphamide,Adriamycin,Cisplatin),AP(Adriamycin,cisplatin)orCE(Carboplatin,Epi-adriamycin).Results:In52pa-tientsnoresidualtumorwasfound;in24patientstherewereresiduallesionslessthan2cmindiame-ter.Postoperativechemotherapyrangedfrom1to12courses.Theoveral5-year-survivalratewas33.6%,with34.9%forstageⅡand29.5%forstageⅢ(P>0.1).The5-year-survivalratesofcaseswithandwithoutresidualtumorwere16.5%and37.6%respectively;theratesofthosecasesreceivinglessormorethan8coursesofchemotherapywere20.0%and60.1%respectivly.Conclu-sion:Theprognosisofovariancancerfolowingcytoreductivesurgeryisinfluencedbyresidualtu-mor,andthenumberofcoursesofchemotherapy.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1996年第10期621-623,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
卵巢肿瘤
综合疗法
OvarianneoplasmsCombinedmodalitytherapy
