摘要
目的研究BRCA-1,Twist在乳腺癌组织中的表达及与乳腺癌临床病理参数的关系,了解两者表达的相关性。方法应用免疫组织化学法检测BRCA-1,Twist在66例乳腺癌组织的表达。结果乳腺癌中Twist的阳性表达与肿瘤的大小、患者年龄、组织学分级无明显相关性(P>0.05),与淋巴结转移率及Ki67的表达率呈正相关(P<0.05)。BRCA-1的阳性表达与组织学分级、肿瘤大小、患者年龄及Ki67的表达率呈负相关(P<0.05),与淋巴结转移率无明显相关性(P>0.05)。BRCA-1,Twist在乳腺癌中的表达呈负相关(r=-0.5,P<0.05)。结论在乳腺癌组织中联合检测Twist,BRCA-1有望成为预测肿瘤预后的生物学指标。
Objective To study the relationship between the expression of the Twist and BRCA-1 and clinical-pathological factors in breast cancer,and the relationship between the expression of the Twist and BRCA-1 was also studied.Methods Expression of Twist and BRCA-1 were detected in 66 cases of breast cancer tissue by immunohistochemistry.Results The positive expression of Twist in breast cancer was significantly correlated with the expression of Ki67 and axillary lymph nodes metastasis status（P0.05）,but not with tumor size,histological grade and age（P0.05）.The positive expression rate of BRCA-1 in breast cancer significantly correlated with histological grade,age,tumor size and the expression rate of Ki67（P0.05）,but not with axillary lymph nodes metastasis status（P0.05）.BRCA-1 and Twist in breast cancer were negatively correlated（r=-0.5,P0.05）.Conclusion In breast cancer,combined detection of BRCA-1 and Twist is very meaningful.They are expected to become tumor biologic indicators for prognosis.
