摘要
目的探讨卵泡晚期超声下均质回声子宫内膜的容受性。方法收集卵泡晚期超声下均质子宫内膜妇女14例(实验组),分别于排卵前和黄体中期取子宫内膜组织,测定白血病抑制因子(LIF)、整合素αvβ3、基质金属蛋白酶-9(MMP9)及血管内皮生长因子(VEGF)水平,其结果与14例卵泡晚期三线征回声内膜妇女(对照组)相比较。结果卵泡晚期对照组和实验组子宫内膜腺体VEGF水平分别为1.39±0.46和0.96±0.37,差别有显著性(P=0.010)。对照组平均LIF、整合素αv、β3水平分别为2.59±0.61、2.60±0.73和2.83±0.57,均高于实验组的1.58±.99、1.85±0.72和1.92±0.91,差别有统计学意义(P=0.003、P=0.011和P=0.004)。结论卵泡晚期均质内膜妇女的子宫内膜容受性低于三线征内膜妇女。
Objective：To explore the receptivity in women with homogeneous endometrium at late follicle phase.Methods：Forteen wowen with homogeneous endometrium seen by transvaginal ultrasound scan at late follicle phase were involved in our infertile outpatient.The endometrial tissues were collected via biopsy at the late follicle phase and mid-luteal phase.Then the parameters including the leukemia inhibitory factor（LIF）,vascular endothelial growth factor（VEGF）,integrin αvβ3 and matrix metalloproteinase-9（MMP-9） were assayed with enzyme-linked immunosorbent assay（ELISAE）.All the results were compared with those of 14 women with trilaminar endometrium at late follicle phase（control group）.Results：In late follicle phase,the mean VEGF level was significantly higher in the control group than in the experiment group（1.39±0.46 vs.0.96±0.37）（P=0.010）.In mid-luteal phase,the mean LIF,integrinαv,β3 level were 2.59±0.61,2.60±0.73 and 2.83±0.57,in the control group,respectively,and both of them were significantly higher than those of 1.58±.99,1.85±0.72 and 1.92±0.91 in experiment group（P=0.003,P=0.011 and P=0.004）.Conclusion： Endometrial receptivity in women with trilaminar echogenity pattern was much better than with homogeneous pattern.
出处
《中国优生与遗传杂志》
2012年第4期127-129,F0003,共4页
Chinese Journal of Birth Health & Heredity
基金
深圳市科技计划项目
项目号:201002089
关键词
卵泡晚期
阴道超声
均质回声
子宫内膜容受性
Transvaginal ultrasound
Late follicle phase
Homogeneous Endometrium
Receptivity
