摘要
目的探讨PCOS与非PCOS患者在控制性超促排卵周期子宫内膜容受性的差异。方法选取8例PCOS不孕患者并行IVF-ET长方案超促排卵治疗,同期选择8例因输卵管因素或男方因素行IVF-ET长方案的非PCOS不孕患者为对照组,在取卵后7天取子宫内膜组织,用免疫组化法测定子宫内膜雌激素受体(ER)、孕激素受体(PR)、整合素αvβ3,用RT-PCR法测定同源框基因HOXA-10的表达。结果控制性促排卵后PCOS组着床窗口期子宫内膜ER、PR表达低于对照组,但差异无统计学意义;αvβ3及HOXA-10表达低于对照组,差异有统计学意义。结论 PCOS患者在控制性超促排卵后仍存在子宫内膜容受性下降的因素。
Objective：To study the difference of the endometrial receptivity during the window of implantation after controlled ovarian hyperstimulation between PCOS patients and non-PCOS patients.Methods： Endometrial samples were collected from 8 PCOS infertility women who use long parallel program superovulation in IVF cycle and 8 non-PCOS infertility patients of tubal factor or male factor in a long line of IVF-ET program as the control group.7 days after egg retrieval,we take endometrial tissue.Immunohistochemical method was used to detect endometrial estrogen receptor（ER）,progesterone receptor（PR） and integrin αvβ3.We use RT-PCR method to detect homeobox gene HOXA-10 expression.Rusults： Compared with those of control group,after controlled ovarian hyperstimulation,the expression of ER and PR of PCOS group were reduced,but the difference was not statistically signigicant;the expression of αvβ3 and HOXA-10 of PCOS group were reduced and the difference was statistically signigicant.Conclusions： PCOS patients still have unfavorable factors in endometrial receptivity after controlled ovarian hyperstimulation.
出处
《中国优生与遗传杂志》
2012年第3期124-126,42,共4页
Chinese Journal of Birth Health & Heredity
