摘要
FOXO转录因子参与多种信号传导通路,并在各种病理生理过程中发挥重要的作用包,括增殖、凋亡,因此FOXO转录因子可作为癌症治疗药物的靶点。就FOXO蛋白在癌症靶向治疗的研究进展作一综述。
Forkhead box O (FOXO) transcription factors are involved in muhiple signaling pathways and play critical roles in a number of pathological and physiological processes including proliferation and apoptosis, so this family of transcription factors appears to be a promising target for future drug discovery for cancers. This review presents the research progress of FOXO proteins as a target for cancer therapy.
出处
《肿瘤研究与临床》
CAS
2012年第3期213-215,共3页
Cancer Research and Clinic
基金
上海市教育委员会科研创新项目(重点项目)(09ZZ25)
上海市科学技术委员会医学引导项目(09411968110)