摘要
外周血循环DNA是指存在于血浆或血清中的胞外游离DNA。研究表明恶性肿瘤患者外周血循环DNA明显高于健康者，其表达水平及基因的改变与肿瘤的发生、发展及预后密切相关。检测外周血循环DNA对恶性肿瘤的早期诊断、疗效监测以及预后评估具有重要价值。就近年来肝细胞癌（HCC）患者外周血循环DNA检测研究进展作一综述。
Peripheral blood DNA is a kind of extracellular free DNA that existing in plasma or serum. Many researchers have already found that circulating DNA level of cancer patients is significantly higher than that of healthy individuals. The alteration in peripheral blood DNA level and gene expression are closely associated with the occurrence, development and prognosis of cancer. Therefore, it is valuable to detect peripheral blood DNA expression for early diagnosis, therapeutic monitoring and prognosis. This article reviews recent advanced progress in research on peripheral blood DNA detection for hepatocellular carcinoma （ncc）.
出处
《肿瘤研究与临床》
CAS
2012年第3期205-208,共4页
Cancer Research and Clinic
基金
南京军区重点课题（092012）
关键词
癌
肝细胞
早期诊断
DNA
治疗结果
预后
Carcinoma, hepatocellular
Early diagnosis
DNA
Treatnent outcome
Prognosis
