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血中循环DNA启动子甲基化与妇科肿瘤的关系 被引量：1

The Relationship between Aberrant Promoter Methylation in Plasma/Serum Circulating DNA and Gynecological Carcinoma
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摘要 妇科恶性肿瘤患者外周血中存在着循环DNA,其含量明显高于健康人水平且具有与肿瘤原发灶相一致的基因异常改变,DNA基因启动子甲基化是基因异常中一项重要的表观遗传学改变,是导致肿瘤抑癌基因、DNA错配修复基因、转移抑制基因等表达沉默的重要分子生物学基础。目前已检测到妇科恶性肿瘤患者外周血循环DNA中有多种基因存在异常甲基化,且与肿瘤患者的临床病理特征存在不同程度的相关性。这使得非创伤性早期诊断肿瘤、及时发现肿瘤的复发或转移、监测疗效、预测预后成为可能。 Circulating DNA was assessed in plasma/serum from gynecological carcinoma patients, and it was found that the concentration of circulating DNA in these patients is higher than in healthy controls. Similar genetic abnormalities occur in the primary tumors of these cancer patients. Promoter methylation is an important epigenetic change. Hypermethylation of multiple genes has been detected in circulating DNA from gynecological cancer patients. Aberrant promoter methylation is a fundamental molecular abnormality leading to transcriptional silencing of tumor suppressor genes, DNA repair genes and metastasis inhibitor genes. The abnormal meth- ylation of multiple genes in the peripheral blood of gynecological tumor patients has been described in recent years. To varying degrees, hypermethylation and abnormal methylation both have a relationship with the clinical characteristics of gynecological carcinoma. Aberrant promoter methylation seen in circulating DNA may prove valuable for cancer detection, evaluating the prognosis, and monitoring.
作者 班蕊 曲芃芃
机构地区 天津市中心妇产科医院
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2011年第6期353-356,共4页 Chinese Journal of Clinical Oncology
基金 天津市自然科学基金资助(编号:08JCYBJC08200)
关键词 循环DNA 甲基化 妇科肿瘤 诊断 预后 Circulating DNA Methylation Gynecological carcinoma Diagnosis Prognosis
分类号 R737.3 [医药卫生—肿瘤]
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参考文献19

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共引文献11

同被引文献11

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中国肿瘤临床
2011年 第6期

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