摘要
目的探讨复方苦参注射液和艾迪注射液在改善晚期肺癌患者生存质量方面的作用。方法60例经病理确诊的晚期肺癌患者按信封法随机分为2组，苦参组30例采用复方苦参注射液加基础治疗，艾迪组30例采用艾迪注射液加基础治疗，静脉滴注2个周期后评价疗效。监测两组近期疗效、临床疗效、Karnofsky评分及肿瘤标志物CA125、CEA的变化。结果治疗后比较客观疗效，苦参组稳定率为83．3％（25／30），艾迪组稳定率为80．0％（24／30），两者比较差异无统计学意义（P〉0．05）；苦参组临床疗效改善率为83．3％（25／30），艾迪组改善率为80．0％（24／30），两者比较差异无统计学意义（P〉0．05）；Kamofsky评分比较，两组增加稳定率均为90．0％（27／30）。艾迪组在改善神疲乏力、气短懒言、烦渴欲饮、腰膝酸软等气虚症状上优于苦参组（均P〈O．05），苦参组在改善大便干结、五心烦热、午后颧红等阴虚内热症状上优于艾迪组（均P〈0．05）。两组的肿瘤标志物CA125和CEA治疗前后下降发生率比较差异无统计学意义（P〉0．05）。苦参组治疗前肝功能异常的3例，治疗后均恢复正常，艾迪组治疗前2例肝功能异常者，治疗后1例恢复正常。结论复方苦参注射液和艾迪注射液治疗晚期肺癌均具有较好的治疗效果，疗效相当。但在改善中医相关症状上两者显示了各自特点。复方苦参注射液能较好改善热毒的症状；艾迪注射液能较好改善气虚的症状。复方苦参注射液对于肺癌合并肝功能异常或伴有疼痛者更为有效。
Objective To explore and compare the therapeutic effects of Fufangkushen injection and Aidi injection on improving quality of life for patients with advanced lung cancer. Methods 60 patients in late stage of lung cancer with pathological diagnosis were split into two groups randomly. 30 patients in Kushen group received Fufangkushen injection plus base therapy, 30 patients in Aidi group received Aidi injection plus base therapy. The data was analyzed on term of tumour size, clinical symptoms, Kamofsky score, cancer marker CA125, CEA, before and after treatment in two groups. The therapeutic effects were evaluatedafter two circles of treatment. Results Compared the short term therapeutic effect, Kushen group had the stability rate for 83.3 %（25/30）, and 80.0 %（24/30） for Aidi group. There was no significant difference.（ P〉 0.05）. Compare the clinical therapeutic effect , Kushen group had the improving rate for 83.3 %（25/30）, and 80.0 %（24/30） for Aidi group. There was no significant difference（P〉0.05）. Compare the Karnofsky score,two groups had equal increasing stability rate （P〉0.05）. Compare decreasing ratio of CEA and CA125 after treatment in two groups , there was no significant difference （P〉0.05）. Conclusion Fufangkushen injection and Aidi injection both have acceptable therapeutic effects in the treatment of patients with later stage lung cancer.The result is equal. As well as they have some other characters themselves to improve lung cancer related symptoms. Fufangkushen injection is better to improve symptoms of heat toxin, and Aidi injection is better to improve symtoms of deficiency Qi. For Fufangkushen injection, it can also adjust disorder of liver function and relieve pain.
出处
《肿瘤研究与临床》
CAS
2012年第3期153-156,共4页
Cancer Research and Clinic
