摘要
目的:确定复方红花微乳中2种成分的最佳配比用量。方法:采用均匀设计法,以镇痛抑制率和出血时间延长率为药效学指标,运用统计学软件处理数据和药效分析相结合筛选组方。结果:联合使用红花提取物剂量20mg/20g和利多卡因剂量2.0mg/20g能明显减少冰醋酸所致小鼠扭体反应次数,延长小鼠全血出血时间。结论:均匀设计法可用于药物联用的配比用量分析,但存在有一定局限,还需对结果进行实验验证。
Objective： To define the optimum proportion of two ingredients in Compound-Carthamus tinctorius microemulsion.Methods： According to uniform design method,6 different doses at 6 different proportions was administrated（transdermal） to observe the analgesic effect to mice by writhing test and the anticoagulant effect by bleeding time by cutting tail.The optimum proportion of ingredients in Compound-Carthamus tinctorius microemulsion was obtained by mathematical analysis combined with pharmacodynamics.Results： The combination of Carthamus tinctorius at 20mg/20g and lidocaine at 2.0mg/20g was appropriately decreased the writhing times and extended the clotting time.Conclusion： The uniform design method could be effectively applied to analyze the multi-drug effects,but the results must be verified by further experiments.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第4期1097-1100,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然基金面上项目(No.81173381)
山西省科技攻关项目(No.2011091014)~~
关键词
红花
利多卡因
均匀设计法
复方红花微乳
组方
配比
Carthamus tinctorius
Lidocaine
Uniform design experimentation
Carthamus Tinctorius Microemulsion
Compound
Proportion
