摘要
目的临床观察促红细胞生成素治疗新生儿缺氧缺血性脑病的疗效。方法选择生后72小时内的中重度缺氧缺血性脑病患儿65例,随机分为EPO治疗组和对照组。对照组采用常规治疗,EPO治疗组给予EPO500U/kg/次,每周3次,共2周,其它治疗同对照组。于生后3天、5天、7天进行新生儿神经学评分;生后7天、14天、28天进行NBNA评分;生后3个月、6个月进行发育商(DQ)测定。结果生后第7日治疗组的神经学评分显著低于对照组。生后的NBNA评分及DQ评分治疗组显著高于对照组。治疗过程中患儿无不良反应。结论 EPO可以促进神经系统症状的早期恢复,并且对于脑损伤患儿的神经系统发育有远期的影响。
Objective To evaluate the neuroprotective effect and safety of neonatal hypoxic - ischemic encephalopathy （HIE） treated with erythropoietin （EPO） . Methods sixty – five neonates with HIE were randomly divided into EPO treated group （ n=30） with the dosage of 500 U/ （kg？time） ,three times a week for 2 weeks and control group （ n=35） without EPO. All supportive measures were same between 2 groups. Neurological scoring was evaluated at d3 ,d5 and d7. Neonatal behavioral neurological assessment （NBNA） was evaluated at d7 ,d14 and d28. The neurodevelopment quote was evaluated at age of 3 and 6 months. Blood pressure ,liver and renal function ,blood electrolytes and blood hemoglobin ,platelet and reticular red blood cell count were monitored before and after treatment in all infants. Results The neurological scoring between two groups had no difference at d3. The significant difference was found at d7（P0.05） . The scoring of NBNA showed a significant difference at all the evaluation times （P0.05）. The neurodevelopment quote was significantly higher in EPO treated group than that in control group at age of 3 and 6 months. There were no differences in the liver and renal function ,blood electrolytes ,blood pressure and platelet count between two groups after treatment ,except the hemoglobin and reticular red blood cell count increased in EPO treated group （All P0.05）.Conclusion Teraphy with EPO on neonatal HIE infants can promote neurological recovery , and there is no serious side effect with EPO treatment .
出处
《当代医学》
2012年第11期138-139,共2页
Contemporary Medicine
关键词
促红细胞生成素
新生儿
缺氧缺血性脑病
Hypoxic - ischemic encephalopathy
Infant newborn
Erythropoietin
