摘要
Bsep蛋白即胆盐输出泵,属于ATP结合盒转运体超家族。对肝细胞细微结构的研究证实其主要表达于肝细胞胆管膜侧,为胆汁生成过程中重要的转运载体。目前大量研究表明,其表达量变化及功能缺失与胆汁淤积发生之间存在密切关系。对Bsep蛋白及其他胆酸转运体的研究有助于全面深入地揭示胆汁淤积发生的部分分子机制,为胆汁淤积的预防、诊治提供理论依据和新的思路。
Bsep protein,also known bile salt export pump,belongs to superfamily of ATP binding cassette（ABC）transporters.The research on hepatocellular minute structure confirmed that it′s mainly expressed in hepatocytic canalicular membrane,is an important transporter of the process of bile excretion.At present many studies indicate that there is close association between Bsep protein expression changes and functional deficiency and cholestasis.Studies of Bsep protein and other bile salt transporters comprehensively and deeply is helpful to reveal molecular mechanism of cholestasis,providing theoretical basis and new ideas for the prevention,diagnosis and treatment of cholestasis.
出处
《医学综述》
2012年第7期967-969,共3页
Medical Recapitulate
基金
浙江省自然科学基金(Y208096)
