摘要
【目的】评价联合检测肌钙蛋白T（cTnT）和N末端脑钠肽前体（NT—proBNP）在评价危重病患者预后中的作用。【方法】通过检测107例危重病患者血清cTnT和NT-proBNP水平，比较APACHE1I〈25分与A—PACHEII≥25分组、有MODS组与无MODS组、死亡组与存活组的cTnT阳性率和NT—proBNP阳性率；比较cTnT和NT—proBNP双阳性组与cTnT或NT—proBNP单阳性组间的病死率。【结果】107例危重病患者A—PACHEⅡ〈25分与APACHEⅡ≥25分组间、有MODS组与无MODS组间、死亡组与存活组间cTnT阳性率及NT—proBNP阳性率比较差异均具有统计学意义（P〈0．05）；cTnT和NT—proBNP双阳性组与cTnT或NT_proBNP单阳性组间病死率比较差异有统计学意义（P〈0．01）。【结论】cTnT阳性或NT—proBNP阳性在评估危重病患者的病情严重程度及预后中发挥重要作用，而联合检测血清cTnT和NT—proBNP可更加有效地判断危重病患者的预后。
[Objective] To evaluate the role of cardiac troponin T（cTnT） and N-terminal B-type natriuretic peptide（NT-proBNP） in prognostic evalution of critical illness patients. [Methods]Serum levels of eTnT and NT- proBNP in 107 patients with critical illness were measured. The positive rates of eTnT and NT-proBNP were compared between APACHEⅡ 〈 25 group and APACHEⅡ ≥25 group, MODS group and non-MODS group, death group and survival group. The mortality rate was also compared between both positive eTnT and NT-proBNP group and positive cTnT or NT-proBNP group. [Results] There were significant differences in the positive rates of cTnT and NT-proBNP among APACHE Ⅱ G25 and APACHE 11≥25 groups, MODS and non-MODS groups, death and survival groups（ P〈0.05）. There were also significant differences in the mortality rate between both positive cTnT and NT-proBNP group and positive cTnT or NT-proBNP group（ P〈0.01）. [Conclusion] Either positive cTnT or NT-proBNP play an important role in evaluating the severity of diseases and predicting the prog-nosis in critical illness patients. The combined detection of cTnT and NT-proBNP can more effectively evaluate the prognosis of critical illness patients.
出处
《医学临床研究》
CAS
2012年第3期410-412,共3页
Journal of Clinical Research
基金
上海市嘉定区科学技术发展基金项目（2009JKK019）
关键词
危重病
肌钙蛋白T
利钠肽
脑
Critical illness
troponin T
natriuretic peptide,brain
