摘要
目的探索吲哚美辛联合茶多酚对荷Lewis肺癌小鼠肿瘤生长的抑制作用.方法建立C57小鼠Lewis肺癌皮下移植瘤模型并随机分为4组:吲哚美辛组、茶多酚组、吲哚美辛联合茶多酚组和生理盐水对照组,每天灌胃给药1次,连续16 d.观察各组小鼠的出瘤时间、瘤体大小和肿瘤抑制率.结果与对照组相比,吲哚美辛和茶多酚低、高剂量对荷Lewis肺癌小鼠肿瘤生长均有显著的抑制作用(P<0.05),二者联合应用低、高剂量对肿瘤的抑制作用高于单独用药(P<0.05).结论联合应用吲哚美辛和茶多酚对荷Lewis肺癌小鼠肿瘤生长具有显著的抑制作用,且有一定增效作用.
Objective To prove the inhibition effects of combination of indomethacin and tea polyphenols on growth of Lewis pulmonary tumor（LLC）in mice.Methods LLC transplant model was built in mice.The model mice were divided randomly into 4 groups：control group,indomethacin group,tea polyphenols group and combination administration group.The tumor volume change and tumor suppressor rate of LLC in mice in four groups were observed.Results The indomethacin and tea polyphenols group had obvious inhibiting effect on the transplanted Lewis pulmonary tumor in mice,compared with control group（P0.05）.The inhibiting effect was enormously enhanced by drug combination of indomethacin and tea polyphenols.Conclusions Combination of indomethacin and tea polyphenols has obvious inhibition effect on the tumor growth of transplanted Lewis pulmonary tumor in mice,which could significantly enhance the inhibition effect to a certain degree,compared with independent administration.
出处
《昆明医学院学报》
2012年第2期23-26,共4页
Journal of Kunming Medical College
基金
云南省自然科学基金资助项目(2009CB089)
